Devita, Hellman, and Rosenberg's Cancer

LWBK1006-09 LWW-Govindan-Review December 12, 2011 18:51

Chapter 9•Principles of Immunotherapy 107

Question 9.10. Which of the following is an approach to cancer immunotherapy?

A. Passive transfer of activated immune cells with antitumor activity

B. Active immunization to enhance antitumor reactions

C. Nonspecific stimulation of immune reactions

D. All of the above

Question 9.11. Which of the following results in inhibition of T cells?

A. CTLA-4

B. CD28

C. B7-1

D. B7-2

Question 9.12. Of 1306 vaccine treatments, what is the overall objective response rate

to vaccine treatment?

A. 3.3%

B. 10.6%

C. 20.4%

D. 49.2%

Question 9.13. Which of the following is NOT an example of active immunization?

A. Whole cell vaccines

B. Heat shock proteins

C. Natural killer (NK) cell vaccines

D. Dendritic cell vaccines

Question 9.14. What is the purpose of adoptive cell transfer therapies?

A. Decreasing the number of reactive T-cells ex vivo and transfer back

to the patient

B. Increasing the number of cytokines ex vivo and transfer back to the

patient

C. Activating and expanding self/tumor-reactive T cells and transfer

back to the patient

D. Modulating CD4+tumor-specific T cells before transferring back to

the patient

Question 9.15. What is the main mechanism of the graft-versus-leukemia effect demon-

strated after a donor lymphocyte infusion?

A. T cells within the lymphocytes recognize target antigens on residual

tumor cells.

B. Enhancing the presence of killer inhibitory receptors (KIRs) recog-

nized by donor NK cells

C. Lack of recognition of minor histocompatibility antigens within

hematopoietic cells

D. Increases in CD8+cells that recognize target antigens on tumor cells