Devita, Hellman, and Rosenberg's Cancer

LWBK1006-09 LWW-Govindan-Review December 12, 2011 18:51

106 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 9.4. Which of the following is an example of a nonmutated melanocyte differ-

entiation antigen?

A. gp100

B. HLA-A*1101

C. CDK4

D. NY-ESO-1

Question 9.5. Which of the following has NOT been a target for the development of

reactive T cells?

A. Prostate-specific antigen (PSA)

B. Carcinoembryonic antigen (CEA)

C. p53

D. Epidermal growth factor receptor (EGFR)

Question 9.6. Expression of the Epstein-Barr virus (EBV) latent gene EBNA is seen in

which of the following cancers?

A. Nasopharyngeal carcinoma

B. Burkitt’s lymphoma

C. T-cell lymphoma

D. All of the above

Question 9.7. A 20 year-old sexually active woman inquires about the role of the human

papilloma virus (HPV) vaccine in relation to cervical cancer. Which of the

following statements regarding the HPV vaccine is correct?

A. It prevents the development of cervical cancer in all patients.

B. It induces regression of cervical cancer tumors.

C. It prevents infection with HPV16 and 18.

D. It prevents the development of cervical cancer in patients infected

with HPV 16 and 18.

Question 9.8. Which of the following is the proposed mechanism for development of

hepatocellular carcinoma secondary to hepatitis B or C?

A. Hepatitis B virus (HBV) produces oncogenic proteins that result in

transformation into malignancy.

B. Increases in the number of somatic mutations in normal hepatocytes

C. Inhibition of normal immune responses to hepatitis infections

D. HBV or hepatitis C virus (HCV) infections lead to cirrhosis, which

develops into hepatocellular carcinoma.

Question 9.9. Which of the following is TRUE of the tumor microenvironment?

A. T cells in the peripheral blood have functional impairment.

B. Expression of lysine is found in myeloid cells, which results in down-

regulation of T-cell receptor (TCR) zeta-chain expression.

C. Monocytes express Gr-1 molecules, leading to upregulation of T cells.

D. Tumors secrete granulocyte-macrophage colony-stimulating factor

(GM-CSF), leading to an accumulation of CD34+suppressor cells.