Devita, Hellman, and Rosenberg's Cancer

LWBK1006-02 LWW-Govindan-Review November 24, 2011 11:18

CHAPTER 2 MOLECULAR

BIOLOGY OF CANCER PART 2

SUNIT SRIVASTAVA•GEORGE R. SIMON

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 2.1. The correct order of mitosis is:

A. Prometaphase, metaphase, anaphase, telophase, prophase

B. Prometaphase, metaphase, prophase, anaphase, telophase

C. Prophase, prometaphase, metaphase, anaphase, telophase

D. Telophase, anaphase, prophase, metaphase, prometaphase

Question 2.2. The cyclin responsible for progressing the cell into and through mitosis

is:

A. Cyclin A

B. Cyclin B

C. Cyclin D

D. Cyclin E

Question 2.3. Which of the following is NOT a means of regulating cyclin-dependent

kinases (CDKs)?

A. Positive regulatory acetylation

B. Negative regulatory phosphorylation

C. CDK inhibitors

D. Cyclin availability

Question 2.4. Which of the following is necessary for the G1/S-phase transition?

A. Cyclin B-CDK1 complex accumulation

B. Cyclins E and A accumulation

C. Dephosphorylation of T14 and Y15

D. CDK1 activation along with binding of CDC20 to anaphase promot-

ing complex/cyclosome (APC/C)

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 6 (Cell Cycle), 7 (Mechanisms

of Cell Death), 8 (Cancer Metabolism), 9 (Angiogenesis), 10 (Invasion and Metastasis), 11 (Cancer Stem Cells), and

12 (Biology of Personalized Cancer Medicine).

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