Devita, Hellman, and Rosenberg's Cancer

LWBK1006-02 LWW-Govindan-Review November 24, 2011 11:18

18 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 2.5. Which of the following has no role in cell-cycle exit?

A. Downregulation of CDKs and cyclins

B. Accumulation of INK4, Cip/Kip, and pRb proteins

C. Reduction in protein synthesis

D. Activation of APC/C

Question 2.6. Activation of antimitogenic signaling involves all of the following

EXCEPT:

A. Interleukin (IL)-2

B. Transforming growth factor (TGF)-

C. Interferon (IFN)-

D. Upregulation of CDK inhibitors and downregulation of cyclins

Question 2.7. Which of the following choices is not true regarding microRNAs?

A. microRNAs encode protein kinases that regulate cell cycle.

B. They regulate mRNA expression.

C. There is at least five clusters of microRNAs targeting mRNA that

encodes cell-cycle regulatory proteins.

D. miR-15a/16 cluster targets cyclin E1 and cyclin D1.

Question 2.8. Which gene is involved in both cell-cycle regulation and DNA repair?

A. TP53

B. NBS1

C. PTTG1

D. CHK2

Question 2.9. Replicative senescence is initiated by means of:

A. Downregulation of cyclins

B. p53 activation

C. Progressive telomere shortening

D. Upregulation of IFNs

Question 2.10. Genes that encode negative regulators of growth and proliferation are:

A. Protooncogenes

B. Oncogenes

C. S-phase genes

D. Tumor suppressor genes

Question 2.11. Which of the following syndromes is associated with a mutation in the

gene encoding Nbs1, leading to microcephaly and a strong predisposition

to lymphoid malignancies?

A. Nijmegen disease

B. Von Hippel–Lindau (VHL) syndrome

C. Familial malignant melanoma syndrome

D. Li–Fraumeni syndrome