Devita, Hellman, and Rosenberg's Cancer

LWBK1006-02 LWW-Govindan-Review November 24, 2011 11:18

Chapter 2•Molecular Biology of Cancer Part 2 21

Question 2.25. Which of the following is NOT a function of pericytes?

A. Paracrine signaling

B. Regulation of vessel diameter

C. Mediation of resistance to antiangiogenic therapy

D. All of the above

Question 2.26. Which of the following is NOT a characteristic of tumor vasculature?

A. Increased dilation

B. Increased tortuosity

C. Increased red blood cell (RBC) flow

D. Decreased support

Question 2.27. Which of the following is NOT considered a primary angiogenic factor?

A. Granulocyte-colony stimulating factor

B. VEGF

C. Angiopoietins

D. Notch-signaling receptors

Question 2.28. Which of the following is NOT a function of VEGF?

A. Stimulate EC division

B. Upregulate various inhibitors of apoptosis

C. Mobilize EC progenitors

D. Create focal areas of breakdown in parental venule basement mem-

branes

Question 2.29. VEGF is inducible by many factors, of which the most important may be:

A. H1F1

B. TSP-1

C. pVHL

D. p53

Question 2.30. Which of the following is NOT thought to inhibit tumor angiogenesis?

A. TSP-1

B. IL-6, IL-8

C. DLL4

D. Vasohibin

Question 2.31. Metronomic low-dose chemotherapy describes:

A. Continuous low-dose treatment with chemotherapeutics

B. Pulse dosing with low doses of chemotherapeutics

C. Continuous low-dose treatment with intermittent pulse dosings of

chemotherapeutics

D. Treatment of refractory tumors with continuous low doses of

chemotherapeutics in conjunction with metronidazole