Devita, Hellman, and Rosenberg's Cancer

LWBK1006-02 LWW-Govindan-Review November 24, 2011 11:18

20 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 2.19. Autophagy does not have a role in:

A. Recycling of normal cellular components

B. Protection against aging

C. Cell lysis caused by surrounding inflammation

D. Innate immunity by protecting against intracellular pathogens

Question 2.20. Which of the following is NOT a feature of necrosis?

A. Rapid cellular swelling

B. Lysosome activation

C. Loss of plasma membrane integrity

D. Release of intracellular components to the extracellular compart-

ment

Question 2.21. The Warburg effect describes:

A. Exponential cell growth in response to an exogenous stimulant.

B. Inefficient energy production by most cancer cells, resulting in rapid

adenosine triphosphate (ATP) depletion and necrotic cell death.

C. Initiation of neoplasia requires two somatic mutations for initiation

of sporadic neoplasms, and hereditary neoplasms require a genetic

plus a somatic mutation.

D. Sculpting of normal human tissues as a result of cell death.

Question 2.22. Unless tumor cells grow an adequate blood vessel supply, they will NOT

grow greater than:

A. <1mm^3

B. 1to2mm^3

C. Approximately 5 mm^3

D. 1cm^3

Question 2.23. Bevacizumab is:

A. A monoclonal antibody to basic fibroblast growth factor (bFGF)

B. A monoclonal antibody to vascular endothelial growth factor (VEGF)

C. A monoclonal antibody to phospholipid lipid growth factor (PLGF)

D. A monoclonal antibody to epidermal growth factor receptor (EGFR)

Question 2.24. The first step in tumor angiogenesis is:

A. A localized degradation of the surrounding basement membrane of a

parental venule

B. Paracrine signaling causing increased leakiness of a parental venule’s

basement membrane

C. An inflammatory response causing recruitment and activation of

leukocytes that mediate angiogenesis

D. Release of endothelial cell (EC) progenitors from the bone marrow