Devita, Hellman, and Rosenberg's Cancer

LWBK1006-28 LWW-Govindan-Review December 9, 2011 16:52

CHAPTER 28 NEOPLASMS OF

THE CENTRAL NERVOUS SYSTEM

JANAKIRAMAN SUBRAMANIAN•GERALD LINETTE

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 28.1. Linkage studies have identified genes associated with neurofibromatosis

type 2 (NF2), Turcot syndrome, and Li-Fraumeni syndrome in which of

the following chromosomes?

A. 10q, 22q, and 17q

B. 22q, 5q, and 17p

C. 5q, 10q, and 17p

D. 5q, 10q, and 17q

Question 28.2. Of the following, the MOST common primary brain tumor in adults in

the United States is:

A. Glioblastoma

B. Meningioma

C. Astrocytoma

D. Oligodendroglioma

Question 28.3. The gene that is frequently altered and plays a key role in the development

of diffuse fibrillary astrocytoma is:

A. p53

B. K-ras

C. MDM2

D. MDM4

Question 28.4. Primary (de novo) glioblastoma multiforme (GBM) is commonly associ-

ated with all of the following, EXCEPT:

A. PTEN inactivation

B. p53 mutation

C. CDKN2A deletion

D. Median age<60 years

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 120 (Molecular Biology of

Central Nervous System Tumors) and 121 (Neoplasms of the Central Nervous System).

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