Devita, Hellman, and Rosenberg's Cancer

LWBK1006-28 LWW-Govindan-Review December 9, 2011 16:52

384 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 28.5. Which gene mutation identified in GBM is frequently seen in younger

patients, and is associated with better prognosis:

A. EGFR

B. p53

C. IDH1

D. Gain in chromosome 4

Question 28.6. Loss of heterozygosity of chromosomes 1p and 19q is common in:

A. GBM

B. Ependymoma

C. Oligodendroglioma

D. Meningioma

Question 28.7. The central nervous system (CNS) tumor that is commonly associated

with NF2 mutations is:

A. GBM

B. Spinal ependymoma

C. Cerebral ependymoma

D. Oligodendroglioma

Question 28.8. Patients with GBM have a higher likelihood of responding to therapy with

epidermal growth factor receptor tyrosine kinase (EGFR-TK) inhibitors

if which of the following biomarkers is present?

A. Methyl guanine methyl transferase (MGMT) gene cytosine methyla-

tion

B. Activated EGFRvIII

C. Retained PTEN function

D. B and C

Question 28.9. The primary CNS neoplasm that is associated with Epstein-Barr virus

(EBV) is:

A. Primary CNS lymphoma

B. Ependymoma

C. Oligodendroglioma

D. GBM

Question 28.10. Which of the following tumors exhibit contrast enhancement on magnetic

resonance imaging (MRI) scan?

A. Pilocytic astrocytoma

B. Grade 2 oligodendroglioma

C. Grade 2 astrocytoma

D. None of the above