Devita, Hellman, and Rosenberg's Cancer

LWBK1006-28 LWW-Govindan-Review December 9, 2011 16:52

392 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Answer 28.20. The answer is C.

Several retrospective case series have shown that incomplete tumor resec-

tion, high tumor grade, supratentorial location, and poor performance

status to be associated with poor outcomes in patients with intracranial

ependymoma. However, improvement in overall survival with adjuvant

radiation is limited to patients with incomplete tumor resection.

Answer 28.21. The answer is A.

In a retrospective analysis of tumor tissue samples from patients with

oligodendrogliomas who received treatment on the EORTC study 26951,

both IDH1 and IDH2 mutations were found to be a prognostic marker

for overall survival.