Devita, Hellman, and Rosenberg's Cancer

LWBK1006-29 LWW-Govindan-Review December 9, 2011 15:36

CHAPTER 29 CANCERS OF

CHILDHOOD

SHALINI SHENOY

DIRECTIONS Each of the numbered items below is followed by lettered answers. Select the

ONE lettered answer that is BEST in each case unless instructed otherwise.

QUESTIONS

Question 29.1. Pediatric malignancies exhibit all of the following characteristics,

EXCEPT:

A. Aggressive, rapid growth

B. Short latency period

C. Associated with exposure to carcinogens

D. Familial association in 10% to 15% of cases

Question 29.2. Genetic abnormalities predispose to malignant disorders in children

because of:

A. Abnormal mechanisms of genomic DNA repair

B. Constitutional activation of molecular pathways of deregulated cel-

lular growth and proliferation

C. Increased function of oncogenes or inactivation of tumor suppressor

genes

D. All of the above

Question 29.3. Which of these cancer predisposition syndromes do not have associated

physical stigmata?

A. Beckwith-Wiedemann syndrome

B. Fanconi anemia

C. Li-Fraumeni syndrome

D. Von Hippel-Lindau disease

Question 29.4. All cancer predisposition syndromes listed below have a dominant mode

of inheritance, EXCEPT:

A. Neurofibromatosis type I

B. Xeroderma pigmentosum

C. Peutz-Jeghers syndrome

D. Multiple endocrine neoplasia (MEN) 2

Corresponding Chapters inCancer: Principles & Practice of Oncology,Ninth Edition: 122 (Molecular Biology of

Childhood Cancers), 123 (Solid Tumors of Childhood), and 124 (Leukemias and Lymphomas of Childhood).

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