Devita, Hellman, and Rosenberg's Cancer

LWBK1006-29 LWW-Govindan-Review December 9, 2011 15:36

394 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 29.5. Which of the following cytogenetic abnormalities is associated with Ewing

sarcoma?

A. t(11;22)

B. t(X;11)

C. del13q14

D. del11p13

Question 29.6. Retinoblastoma is a heritable tumor that is often bilateral. All of the

following statements regarding retinoblastoma are true, EXCEPT:

A. Loss of heterozygosity (LOH) of the wild-type allele at the Rb1 locus

results in the disease.

B. Rb1 loss abrogates control of cell-cycle regulation from the G1 to S

phase.

C. Both Rb1 and EWS genes are implicated in the development of

retinoblastoma.

D. In a developing retina, inactivation of Rb1 is necessary and sufficient

for tumor formation.

Question 29.7. Which of the following pediatric conditions is NOT associated with

known genetic events that predispose to tumor development in children?

A. Retinoblastoma

B. Neuroblastoma

C. Ewing sarcoma

D. Hodgkin’s lymphoma

Question 29.8. Which of the following syndromes is associated with predisposition for

developing renal cell carcinoma?

A. Von Hippel-Lindau

B. Beckwith-Weidemann

C. WAGR

D. Simpson-Golabi-Behmel

Question 29.9. Patients with MEN1 syndrome are predisposed to developing all of the

following endocrine tumors, EXCEPT:

A. Parathyroid adenoma

B. Pancreatic islet cell tumor

C. Pheochromocytoma

D. Pituitary adenoma

Question 29.10. WAGR, a syndrome complex with deletions at chromosome 11q13, the

locus of the WT1 gene, predisposes to Wilms’ tumor and involves the

following structures (choose one answer):

A. Iris, genitourinary (GU) system, IQ

B. Ovaries, gut, and central nervous system (CNS)

C. CNS, heart, and kidneys

D. None of the above