Devita, Hellman, and Rosenberg's Cancer

LWBK1006-30 LWW-Govindan-Review December 12, 2011 19:35

Chapter 30•Lymphomas 415

Question 30.10. Which of the following is not a mature B-cell neoplasm?

A. Primary effusion lymphoma

B. Anaplastic large cell lymphoma

C. Hairy cell leukemia

D. Lymphomatoid granulomatosis

Question 30.11. Genetic abnormalities in CLL/SLL can influence prognosis and include

all of the following, EXCEPT:

A. t(11;18)(q21;q21) and/ori(7q)(q10)

B. 11q23 deletion involving the ATM gene, which is also seen in T-cell

prolymphocytic leukemia (T-PLL)

C. 17p13 deletion involving the p53 tumor suppressor gene

D. Trisomy 12 and/or 13q14 deletion (the latter also seen in myeloma)

Question 30.12. All of the following are true about CLL/SLL, EXCEPT:

A. Deletion 17p13 predicts poor survival and fludarabine resistance.

B. CD38 expression and ZAP-70 are associated with poor prognosis.

C. Unmutated Ig V region is associated with good prognosis.

D. Autoimmune hemolytic anemia and immune thrombocytopenia

require therapy with glucocorticoids, intravenous gammaglobulin,

and/or rituximab.

Question 30.13. Which of the following B-cell lymphomas may have CD10 positive and

t(14;18) translocation:

A. Lymphoplasmacytic lymphoma

B. Follicular lymphoma

C. Diffuse large B-cell lymphoma (DLBCL)

D. B and C

Question 30.14. All of the following apply to lymphoplasmacytic lymphomas, EXCEPT:

A. It is a neoplasm of small B lymphocytes, plasmacytoid lymphocytes,

and plasma cells lacking CD5, CD10, and CD23, with strong expres-

sion of sIg and CD20, differentiating it from CLL/SLL.

B. Translocation oft(9;14)(p13;q32) and rearrangement of the PAX-5

gene.

C. Thalidomide (an immunomodulatory agent derivative) and borte-

zomib (a proteosome inhibitor) are not active in these lymphomas.

D. Monoclonal serum IgM paraproteinemia, with or without hyper-

viscosity, characterizes Waldenstrom’s macroglobulinemia. Clinical

presentation commonly involves the marrow, nodes, and spleen, but

rarely involves pulmonary, small bowel, and renal sites (the latter

seen with mixed cryoglobulinemia and hepatitis C virus).