Devita, Hellman, and Rosenberg's Cancer

LWBK1006-30 LWW-Govindan-Review December 12, 2011 19:35

416 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 30.15. Which of the following T-cell malignancies is associated with the presence

of T cell receptor?

A. Large granular lymphocytic leukemia

B. Hepatosplenic T-cell lymphoma

C. Angioimmunoblastic lymphoma

D. Mycosis fungoides (MF)

Question 30.16. Higher risk of CNS relapse may occur in all of the following large cell

lymphoma presentations, EXCEPT:

A. Paranasal sinus involvement; epidural involvement

B. Bone marrow involvement and high IPI score

C. Testicular involvement

D. Tonsillar involvement

Question 30.17. Regarding the staging workup of NHL and HL, all are true, EXCEPT:

A. The fluorodeoxyglucose (FDG) positron emission tomography (PET)

scan is highly reliable in finding disease activity in intermediate/high-

grade lymphoma and HL.

B. The FDG-PET scan is less reliable in detecting extranodal marginal

zone lymphoma.

C. The FDG-PET scan has replaced gallium scans in staging lymphoma.

D. The FDG-PET scan is not useful in the evaluation of splenic involve-

ment.

Question 30.18. Regarding splenic marginal zone lymphoma (SMZL), all are true,

EXCEPT:

A. Patients can have circulating “villous” lymphocytes; most tumors are

CD5 negative and express CD19, CD20, CD22, and bcl-2.

B. Hemoglobin<12 g/dL, LDH>normal, and albumin<3.5 g/dL are

risk factors predicting a shorter survival of 50%.

C. Disease is confined only to the spleen.

D. Observation, splenectomy, and chemotherapy with alkylating agents

and purine analogs similar to follicular lymphoma are used in these

patients.

Question 30.19. Regarding follicular lymphoma, all are true, EXCEPT:

A. Radiotherapy (RT) is the standard of care in early-stage disease (CS

I and II).

B. Radioimmunotherapy, novel monoclonal antibodies, proteosome

inhibitors, and tumor vaccines have all been associated with

responses.

C. Autologous stem cell transplantation is curative for patients with

advanced-stage disease.

D. Translocations involving BCL6 are seen in DLCBL transformation.