Devita, Hellman, and Rosenberg's Cancer

LWBK1006-04 LWW-Govindan-Review November 24, 2011 11:19

Chapter 4•Etiology of Cancer Part 2 59

Question 4.11. Radiation was used to treat which of the following disease conditions?

A. Enlarged thymus glands

B. Peptic ulcers

C. Ankylosing spondylitis

D. All of the above

Question 4.12. Which of the following statements is TRUE about radiation exposure,

tissue sensitivity, and latent period?

A. Evidence suggests that acute and chronic myelogenous leukemias are

very sensitive to induction after radiation exposure.

B. Latent period is defined as the period of time between radiation expo-

sure and the appearance of radiation-induced tumors.

C. The peak incidence for the development of radiation-induced

leukemia occurs between 0 and 2 years after exposure.

D. Both A and B.

Question 4.13. Which of the following is TRUE regarding theoretic models of radiation

interaction?

A. Linear and linear-quadratic models have been described.

B. Cancer risk is directly proportional to radiation dose in the linear

model.

C. Cancer risk is directly proportional to radiation dose at low dose and

a function of square of the dose at higher dose in the linear-quadratic

model.

D. All of the above.

Question 4.14. In regard to high linear energy transfer (LET) radiation, which of the

following is NOT true?

A. Ionization tracks through an individual cell are few.

B. Because of the high density of this type of exposure, the probability

of producing complex effects is high.

C. The dose response in this case is nonlinear.

D. None of the above.

Question 4.15. Which of the following regarding radon is TRUE?

A. Radon is a major source of high LET radiation to the general popu-

lation.

B. Radon is chemically active and charged.

C. Radon exposure is not a risk factor for lung cancer.

D. Bystander effect is not true with radon exposure.

Question 4.16. Match the following:

A. Younger age of exposure 1. High risk of cancer induction

B. Middle age at exposure 2. Low risk of cancer induction

C. High penetrance genes 3. Ataxia-telangiectasia

D. Breast cancer 4. High probability of cancer induction