Devita, Hellman, and Rosenberg's Cancer

LWBK1006-04 LWW-Govindan-Review November 24, 2011 11:19

60 DeVita, Hellman, and Rosenberg’s CANCER: Principles and Practice of Oncology Review

Question 4.17. Which of the following plays a role in second cancers after radiation

therapy?

A. Age of exposure

B. Body size

C. Genetic susceptibility

D. All of the above

Question 4.18. Which of the following is a mechanism of radiation-induced cancer?

A. DNA double-strand break induction

B. Telomere dysfunction and instability

C. Cytogenetic damage in progeny of irradiated cells

D. All of the above

Question 4.19. Which of the following influences development of skin cancer?

A. Presence of skin pigment

B. Latitude of location on earth

C. Family history of skin cancer

D. All of the above

Question 4.20. Which of the following statements is TRUE regarding malignant

melanoma?

A. Malignant melanoma is more a result of chronic exposure to sunlight

than acute exposure.

B. History of sunburns does not predispose one to malignant melanoma.

C. Melanoma development is independent of tumor suppressor gene

pathways and mutated oncogenes.

D. Familial form of malignant melanoma involves deletions or mutations

in CDKN2A.

Question 4.21. Which of the following is NOT TRUE regarding asbestos?

A. Asbestos and tobacco act in synergy to induce lung cancer.

B. Approximately 5% of all lung cancers are attributable to exposure

to asbestos.

C. p53 mutations are common in mesothelioma.

D. B and C.

Question 4.22. Obesity is defined as a body mass index (BMI) (Quetelet’s Index) greater

than which of the following values?

A. 24 kg/m^2

B. 26 kg/m^2

C. 28 kg/m^2

D. 30 kg/m^2