196
Table 1
Amplification or deletion of genes involved in esophageal adenocarcinoma
Amplification/
Deletion Gene Ref.Amplification Anaplastic lymphoma receptor tyrosine kinase (ALK) [ 11 ]
AKT serine/threonine kinase 1 (AKT1) [ 12 ]
ATM serine/threonine kinase (ATM) [ 13 ]
ATP binding cassette subfamily B member 1 (ABCB1,
MDR)[ 13 ]ATP binding cassette subfamily C member 4 (ABCC4) [ 14 ]
B-Cell CLL/Lymphoma 9 (BCL9) [ 15 ]
B lymphoma Mo-MLV insertion region 1 homolog
(Bmi-1)[ 16 ]Calneuron 1 (CALN1) [ 11 ]
Cell division protein kinase 6 (CDK6) [ 17 ]
Cerebellin 4 precursor (CBLN4) [ 11 ]
Cortactin (CTTN, EMS1) [ 14 ]
Cyclin D1 (CCND1) [ 12 ] [ 14 ]
Cyclin E1 (CCNE1) [ 12 ]
Cyclin E [ 18 ]
c-Myc (Myc) [ 11 , 12 , 15 , 19 , 20 ]
Cutaneous T-cell lymphoma-associated antigen 1
(CTAGE1)[ 15 ]DEAH-box helicase 15 (DHX15, DDX15) [ 13 ]
Dual specificity tyrosine phosphorylation regulated
kinase 2 (DYRK2)[ 12 , 21 ]Ephrin type-B receptor 4 is a protein (EPHB4) [ 22 ]
Epidermal growth factor receptor (EGFR) [ 12 , 17 , 19 , 20 , 23 ]
Family with sequence similarity 84 member B (FAM84B) [ 11 ]
Fibroblast growth factor receptor 2 (FGFR2) [ 24 ]
Fibroblast growth factor 3 (FGF3) [ 14 ]
GATA binding protein 4 (GATA4) [ 11 ]
Granulysin (GNLY) [ 13 ]
Growth factor receptor-bound protein 7 gene (GRB7) [ 25 ]
Forkhead Box A1 (FOXA1, HNF3alpha) [ 12 ]
Human epidermal receptor growth factor 2
(ERBB2/HER-2)[ 19 , 23 , 25 – 28 ](continued)Katherine T. W. Lee et al.