Cannabinoids

Effects of Cannabinoids on Neurotransmission 351

Table 5.

Endogenous tone at CB

receptors inhibiting neuroeffector transmission ( 1

continuedonnextpage

)

Neurotransmitter Species

Tissue

Method

Identification of endogenous tone

1

Reference(s)

Glutamate

Rat

Cortex

Electrophysiology (patch clamp) Inverse agonist (SR 141716)

Auclair et al. 2000

Glutamate

Rat

Caudate-putamen

Electrophysiology (patch

clamp) Inverse agonist (AM 281)

Huang et al. 2001

Glutamate

Rat

Hippocampus

Electrophysiology

(extracellular

recording)

Inverse agonist (SR 141716)

Ameri et al. 1999

GABA

Rat

Hippocampus

Electrophysiology (patch clamp) Inhibitor

of endocannabinoid reuptake

(AM 404)

Wilson and Nicoll 2001

Noradrenaline

Guinea-pig Hippocampus

(^3) [
H]Noradrenaline release
Inverse agonists (SR 141716, AM 251, AM281)
Schlicker et al. 1997, 2002
Noradrenaline
Rat
Vas deferens
Contraction
Inverse agonists (SR 141716, LY 320135),inhibitorofendocannabinoiddegradation(phenylmethylsulfonyl fluoride, PMSF)
Christopoulos et al. 2001
Noradrenaline,ATP
Mouse
Vas deferens
Contraction
Inverse agonist (SR 141716)
Pertwee et al. 1996a
Noradrenaline
Mouse
Vas deferens
(^3) [
H]Noradrenaline release
Inverse agonist (SR 141716), knockoutmouse generated by Zimmer et al. 1999
Schlicker et al. 2003
Dopamine
Guinea-pig Retina
(^3) [
H]Dopamine release
Inverse agonist (SR 141716)
Schlicker et al. 1996
Acetylcholine
Man
Cortex
(^3) [
H]Acetylcholine release
Inverse agonist (SR 141716), partial ago-nist (O-1184), inhibitor of endocannabi-noid reuptake (AM 404)
Steffens et al. 2003
Acetylcholine
Rat
Hippocampus
(^3) [
H]Acetylcholine release
Inverse agonists (SR 141716, AM 281)
Gifford and Ashby 1996;Gifford et al. 1997b, 2000
Acetylcholine
Mouse
Hippocampus
(^3) [
H]Acetylcholine release
Inverse agonist (SR 141716), knockoutmouse generated by Zimmer et al. 1999
Kathmann et al. 2001a,b
Acetylcholine
Guinea-pig Hippocampus
(^3) [
H]Acetylcholine release
Inverse agonist (SR 141716)
Schultheiß et al. 2004
Acetylcholine, ATP Mouse
Urinary bladder
Contraction
Inverse agonist (SR 141716)
PertweeandFernando1996