656 J.A. Ramos et al.
Pérez-Rosado A, Manzanares J, Fernández-Ruiz J, Ramos JA (2000) Prenatal∆^9 -tetrahydro-
cannabinol exposure modifies proenkephalin gene expression in the fetal rat brain:
sex-dependent differences. Brain Res Dev Brain Res 120:77–81
Pérez-Rosado A, Gomez M, Manzanares J, Ramos JA, Fernández-Ruiz J (2002) Changes
in prodynorphine and POMC gene expression in several brain regions of rat fetuses
prenatally exposed to∆^9 -tetrahydrocannabinol. Neurotox Res 4:211–218
Ramos JA, de Miguel R, Cebeira M, Hernández ML, Fernández-Ruiz J (2002) Exposure to
cannabinoids in the development of endogenous cannabinoid system. Neurotox Res
4:363–372
Rodriguez de Fonseca F, Cebeira M, Fernández-Ruiz JJ, Navarro M, Ramos JA (1991) Effects
ofpre-andperinatalexposuretohashishextractsontheontogenyofbraindopaminergic
neurons. Neuroscience 43:713–723
Romero J, García-Palomero E, Fernández-Ruiz JJ, Ramos JA (1996) Involvement of GABA-B
receptors in the motor inhibition produced by agonists of brain cannabinoid receptors.
Behav Pharmacol 7:299–302
Romero J, García-Palomero E, Berrendero F, García-Gil L, Hernández ML, Ramos JA,
Fernández-Ruiz JJ (1997) Atypical location of cannabinoid receptors in white matter
areas during rat brain development. Synapse 26:317–323
Rubio P, Rodríguez de Fonseca F, Muñoz RM, Ariznavarreta C, Martin JL, Navarro M (1995)
Long-term behavioral effects of perinatal exposure to∆^9 -tetrahydrocannabinol in rats:
possible role of pituitary-adrenal axis. Life Sci 56:2169–2176
RubioP,RodríguezdeFonsecaF,MartinJL,delArcoI,BartoloméS,VillanúaMA,NavarroM
(1998) Maternal exposure to low doses of∆^9 -tetrahydrocannabinol facilitates morphine-
induced place conditioning in adult male offspring. Pharmacol Biochem Behav 61:229–
238
Rueda D, Navarro B, Martínez-Serrano A, Guzman M, Galve-Ropert I (2002) The endo-
cannabinoid anandamide inhibits neural progenitor cell differentiation through atten-
uation of the Rap1/B-Raf/ERK pathway. J Biol Chem 277:46645–46650
Sillence DJ, Allan D (1998) Utilization of phosphatidylcholine and production of diacylglyc-
erol as a consequence of sphingomyelin synthesis. Biochem J 331:251–256
Vela G, Fuentes JA, Bonnin A, Fernández-Ruiz JJ, Ruiz-Gayo M (1995) Perinatal exposure
to∆^9 -tetrahydrocannabinol (∆^9 -THC) leads to changes in opioid-related behavioral
patterns in rats. Brain Res 680:142–147
Vela G, Martin S, Garcia-Gil L, Crespo JA, Ruiz-Gayo M, Fernández-Ruiz JJ, Garcia Lecum-
berry C, Pelaprat D, Fuentes JA, Ramos JA, Ambrosio E (1998) Maternal exposure to∆^9 -
tetrahydrocannabinol facilitates morphine self-administration behavior and changesregional binding to centralμ-opioid receptors in adult offspring female rats. Brain Res
807:101–109
Walters DE, Carr LA (1988) Perinatal exposure to cannabinoids alters neurochemical devel-
opment in the rat brain. Pharmacol Biochem Behav 29:213–216
Yang ZM, Paria BC, Dey SK (1996) Activation of brain-type cannabinoid receptors interferes
with preimplantation mouse embryo development. Biol Reprod 55:756–761
Zhou D, Song ZH (2001) CB1 cannabinoid receptor-mediated neurite remodeling in mouse
neuroblastoma N1E-115 cells. J Neurosci Res 65:346–353