Synthetic Biology Parts, Devices and Applications

(Nandana) #1

156 7 Splicing and Alternative Splicing Impact on Gene Design


47 Abelson, J., Trotta, C.R., and Li, H. (1998) tRNA splicing. J. Biol. Chem., 273 ,
12685–12688.
48 Pan, Q., Shai, O., Lee, L.J., Frey, B.J. et al. (2008) Deep surveying of alternative
splicing complexity in the human transcriptome by high-throughput
sequencing. Nat. Genet., 40 , 1413–1415.
49 Wang, E.T., Sandberg, R., Luo, S., Khrebtukova, I. et al. (2008) Alternative
isoform regulation in human tissue transcriptomes. Nature, 456 , 470–476.
50 Roy, B., Haupt, L.M., and Griffiths, L.R. (2013) Review: alternative splicing (AS)
of genes as an approach for generating protein complexity. Curr. Genomics, 14 ,
182–194.
51 McManus, C.J. and Graveley, B.R. (2011) RNA structure and the mechanisms of
alternative splicing. Curr. Opin. Genet. Dev., 21 , 373–379.
52 Breitbart, R.E., Nguyen, H.T., Medford, R.M., Destree, A.T. et al. (1985) Intricate
combinatorial patterns of exon splicing generate multiple regulated troponin T
isoforms from a single gene. Cell, 41 , 67–82.
53 Hastings, K.E., Bucher, E.A., and Emerson, C.P. Jr. (1985) Generation of troponin
T isoforms by alternative RNA splicing in avian skeletal muscle. Conserved and
divergent features in birds and mammals. J. Biol. Chem., 260 , 13699–13703.
54 Medford, R.M., Nguyen, H.T., Destree, A.T., Summers, E. et al. (1984) A novel
mechanism of alternative RNA splicing for the developmentally regulated
generation of troponin T isoforms from a single gene. Cell, 38 , 409–421.
55 Briggs, M.M. and Schachat, F. (1993) Origin of fetal troponin T: developmentally
regulated splicing of a new exon in the fast troponin T gene. Dev. Biol., 158 ,
503–509.
56 Stefancsik, R., Randall, J.D., Mao, C., and Sarkar, S. (2003) Structure and
sequence of the human fast skeletal troponin T (TNNT3) gene: insight into the
evolution of the gene and the origin of the developmentally regulated isoforms.
Comp. Funct. Genomics, 4 , 609–625.
57 Wang, J. and Jin, J.P. (1997) Primary structure and developmental acidic to basic
transition of 13 alternatively spliced mouse fast skeletal muscle troponin T
isoforms. Gene, 193 , 105–114.
58 Briggs, M.M. and Schachat, F. (1996) Physiologically regulated alternative
splicing patterns of fast troponin T RNA are conserved in mammals.
Am. J. Physiol., 270 , C298–C305.
59 Brotto, M.A., Biesiadecki, B.J., Brotto, L.S., Nosek, T.M. et al. (2006) Coupled
expression of troponin T and troponin I isoforms in single skeletal muscle fibers
correlates with contractility. Am. J. Physiol. Cell Physiol., 290 , C567–C576.
60 Gomes, A.V., Barnes, J.A., Harada, K., and Potter, J.D. (2004) Role of troponin T
in disease. Mol. Cell. Biochem., 263 , 115–129.
61 Ogut, O., Granzier, H., and Jin, J.P. (1999) Acidic and basic troponin T isoforms
in mature fast-twitch skeletal muscle and effect on contractility. Am. J. Physiol.,
276 , C1162–C1170.
62 Pan, B.S. and Potter, J.D. (1992) Two genetically expressed troponin T fragments
representing alpha and beta isoforms exhibit functional differences. J. Biol.
Chem., 267 , 23052–23056.
Free download pdf