b2815 Tissue Engineering and Nanotheranostics “9.61x6.69”122 Tissue Engineering and Nanotheranostics
Lee et al. presented a seed-mediated growth mechanism to com-
bine inorganic–inorganic oxide materials to form a Janus-shaped struc-
ture.81,82 Firstly, thermal decomposition method was employed for the
preparation of hydrophobic Fe 3 O 4 with variable sizes and then these
Fe 3 O 4 nanoparticles injected into a trioctylamine solution of
Mn(CH 3 CO 2 ) 2 and oleic acid were used to start the growth process.83,84
The obtained morphologies at different steps are shown in Fig. 14.
Ultra-small iron oxide provided the opportunity for the formation of a
uniform thick layer of a MnO in the form of shell around Fe 3 O 4 and
heterogeneous nucleation occurred when the Fe 3 O 4 nanoparticles were
Fig. 14. (a) Seeds of iron oxide with different sizes, (b) seed-dependent growth of
Fe 3 O 4 –MnO magnetic hybrid nanoparticles, (c)–(e) TEM images of Fe 3 O 4 (5 nm)@
MnO, Fe 3 O 4 (11 nm)/MnO dumbbell-like, and Fe 3 O 4 (21 nm)/MnO flower,
respectively. Reprinted with permission from Refs. 81 and 82.^