“9.61x6.69” b2815 Tissue Engineering and Nanotheranostics
Magnetic Nanohybrids for Magnetic Resonance Imaging 12311 nm in size. The TEM pictures showed the core–shell, dumbbell and
flower-shaped morphology of Fe 3 O 4 –MnO magnetic nanohybrid struc-
ture. Later, they used PEG to modify the surface of Janus nanoparticles
to enhance the biocompatibility.^85
In 2006, Chung-Yuan Mou developed a facile strategy to fabricate
uniform magnetic-luminescent multifunctional well-ordered mesoporous
structure which has good application in the biomedical field.^86 Similar
decomposition methods were employed to prepare Fe 3 O 4 nanoparticles
and were dispersed in cyclohaxene. Subsequently, reverse microemul-
sion technique was used to synthesize homogeneous silica shell using
TEOS and was hydrolyzed by NH 4 OH at 50°C. Finally, fluorescent dye
N-1-(3–trimethoxy-silylpropyl)-N-fluoresceyl thiourea (FITC–APT–
MS) was introduced to synthesize Janus magnetic mesoporous silica/
luminescent structure. The self-assembly process is illustrated in
Fig. 15(a). The corresponding TEM of the core–shell and Janus-shaped
structure are shown in Figs. 15(b) and 15(c). Further confirmation was
Fig. 15. (a) Synthetic illustration of tumbler-like mesoporous silica nanocomposites
(TMSNs). (b) TEM image of Fe3O4@SiO2 core–shell nanoparticles, (c) TEM and
(d) HRTEM pictures of TMSNs. Reprinted with permission from Ref. 86.^