Science - USA (2019-08-30)

with equivalent residues in the kinase domain ofPfCLK1 (fig. S1), a variant ofPfCLK3 was generated where Gly^449 inPfCLK3 was su ...

sensitivity to an inhibitor. By swapping residues between the kinases, we introduced inhibitor insensitivity into our target kin ...

(table S4). Among these“on-target”down- regulated genes were those involved in key par- asite processes, such as egress and inva ...

up-regulated (table S4). Among these were genes associated with RNA processing, such as splicing factor 1 (PF3D7_1321700) and pr ...

including the liver stage. This suggests that targetingPfCLK3 might be a novel strategy for developing curative treatments for m ...

L. N. Johnson, Protein kinase inhibitors: Contributions from structure to clinical compounds.Q. Rev. Biophys. 42 ,1– 40 (2009). ...

RESEARCH ARTICLE ◥ COMPUTER SCIENCE Superhuman AI for multiplayer poker Noam Brown1,2and Tuomas Sandholm1,3,4,5 In recent years ...

a dummy player can be added to the two-player game to make it a three-player zero-sum game). Even approximating a Nash equilibri ...

will rely on its search algorithm (described in a later section) to compute a response in real time to such“off-tree”actions. Th ...

and computation would enable a finer-grained blueprint that would lead to better performance but would also result in Pluribus u ...

precomputed blueprint strategy; another is a modified form of the blueprint strategy in which the strategy is biased toward fold ...

was determined to be profitable with apval- ue of 0.028. The performance of Pluribus over thecourseoftheexperimentisshowninFig.5 ...

ARCHAEOLOGY Late Upper Paleolithic occupation at Cooper’s Ferry, Idaho, USA, ~16,000 years ago Loren G. Davis^1 *, David B. Mads ...

and overlies LU2 and LU1 alluvium. For the purposes of this Report we focus on LU3 to LU1 (Fig. 2). Description of stratigraphic ...

(FCR), and also 86 faunal bone fragments and 1 river mussel shell fragment (Fig. 2 and tables S3 and S4). Most bone fragments la ...

F129 and F143 probably occupied a contempora- neous surface. The LU3 deposit between 411.55 masl and the lower contact with LU2 ...

theendoftheLU3occupationalphaseorthe beginning of the LU4 occupational phase. A projectile point blade fragment made on CCS (73- ...

into the Americas along the Pacific coast. This does not preclude subsequent human migrations through the IFC at a later time, a ...

N. Williamson-Cloud for their support of archaeological research at the Cooper’s Ferry site. L.G.D. acknowledges J. Cramer and R ...

ARCHAEOLOGY Archaeological assessment reveals Earth’s early transformation through land use ArchaeoGLOBE Project*† Environmental ...