Nature - 2019.08.29

reSeArcH Article microlitres of Laemmli buffer 2× was added to the resin and heated for 5 min at 95 °C. Results are representati ...

Article reSeArcH influx rate was calculated as the relative increase in isotope content over time (using the SLOPE function of M ...

reSeArcH Article Extended Data Fig. 1 | Overexpression of mouse MITOK causes mitochondrial dysfunction. a, Membrane (pellet) and ...

Article reSeArcH Extended Data Fig. 2 | Localization and function of human MITOK isoforms. a, Immunolocalization of MITOK (green ...

reSeArcH Article Extended Data Fig. 3 | See next page for caption. ...

Article reSeArcH Extended Data Fig. 3 | MITOK is a cation channel. a, b, Western blots and Coomassie staining of MITOK expressed ...

reSeArcH Article Extended Data Fig. 4 | MITOK alone is insensitive to ATP. a, Activity of MITOK in 100  mM Na-gluconate. n =  5 ...

Article reSeArcH Extended Data Fig. 5 | See next page for caption. ...

reSeArcH Article Extended Data Fig. 5 | Biophysical characterization of recombinant human MITOSUR and mouse MITOK. a–c, Thermal ...

Article reSeArcH Extended Data Fig. 6 | MITOK and MITOSUR interact in situ. a, P roteinase K protection assay in isolated HeLa m ...

reSeArcH Article Extended Data Fig. 7 | Genetic ablation of MITOK in HeLa cells. a, Schematic of the MITOK gene. The expanded re ...

Article reSeArcH Extended Data Fig. 8 | See next page for caption. ...

reSeArcH Article Extended Data Fig. 8 | Loss of MITOK causes mitochondrial dysfunction. a, OCR measurements in wild-type and MIT ...

1 nature research | reporting summary October 2018 Corresponding author(s): Rosario Rizzuto Diego De Stefani Last updated by aut ...

2 nature research | reporting summary October 2018 For a reference copy of the document with all sections, see nature.com/docume ...

3 nature research | reporting summary October 2018 Animals and other organisms Policy information about studies involving animal ...

Article https://doi.org/10.1038/s41586-019-1503-x BCAA catabolism in brown fat controls energy homeostasis through SLC25A44 take ...

Article reSeArcH (Fig. 1f, g). Whereas the basal SUV in the liver and heart was higher than in BAT, no significant change was se ...

reSeArcH Article seen in muscle and liver temperature (Fig. 2c, Extended Data Fig. 3g). Notably, BckdhaUCP1-KO mice were intoler ...

Article reSeArcH of BckdhaUCP1 -KO  mice contained significantly higher levels of tri- glycerides than those of controls (Extend ...