Science - USA (2020-01-17)

IgG (200mg) were given every 3 days starting day 0. Clinical scoring was done as previously described ( 91 ). Imiquimod induced ...

C. U. Blanket al., Defining‘T cell exhaustion’.Nat. Rev. Immunol. 19 ,665–674 (2019). doi:10.1038/s41577-019-0221-9; pmid: 3157 ...

RESEARCH ARTICLE SUMMARY ◥ ADVANCED IMAGING Correlative three-dimensional super-resolution and block-face electron microscopy of ...

RESEARCH ARTICLE ◥ ADVANCED IMAGING Correlative three-dimensional super-resolution and block-face electron microscopy of whole v ...

modality highlights features not readily appar- ent from the EM data alone, such as excep- tionally long or convoluted endosomes ...

8 K necessitated a fresh, data-driven approach (fig. S11 and text S5b) to the problem of cor- rectly assigning and integrating t ...

via freeze substitution ( 19 – 21 ), heavy metal staining, and embedding in Eponate 12 resin (fig. S12C). After coarse trimming ...

believed to play a key role in mitochondrial quality control by sequestering unfolded or oxidized mitochondrial proteins and tra ...

(Fig. 4C), or hollow spheres (Fig. 4D) formed with increasing volume (fig. S17, lower rows). This may serve to regulate reaction ...

in multicellular organisms ( 63 , 64 ). Although the molecular context and ultrastructure of cellular adhesions to rigid artific ...

cohort of seven GNPs and nine CGNs. These collectively contained >2000mm^3 of two nu- clear domain reference proteins: mEmera ...

Analysis of H3.3 relationships to hetero- chromatin and euchromatin also revealed sub- stantial differences between GNP and CGN ...

way mutually consistent with the findings of SR, EM, live imaging, and biochemistry. Of course, the value of cryo-SR/FIB-SEM to ...

adapted to a commercial cryogenic vacuum transfer system (Quorum Technologies, PP3010T; fig. S6 and text S3). SIM images were pr ...

B. Titze, C. Genoud, Volume scanning electron microscopy for imaging biological ultrastructure.Biol. Cell 108 , 307– 323 (2016) ...

RESEARCH ARTICLE ◥ MASS EXTINCTION On impact and volcanism across the Cretaceous-Paleogene boundary Pincelli M. Hull^1 *†, André ...

for a volcanogenic driver. Despite advances in chronology, the timing of the most volumi- nous Deccan eruptions relative to the ...

the majority (87%) of degassing taking place beforetheK/Pgboundary[after( 10 )]; (ii) case 2 (50:50), with half of the degassing ...

absolute errors (MAEs) for cases 3 and 4 as compared with cases 1 and 2 (Table 2). The temporal dynamics ofd^13 Cincases3and5 al ...

immediatelyaftertheimpact(case2)were limited by extinction-related changes to the carbon cycle, including the reduction in CaCO ...