Nature - USA (2020-01-16)

378 | Nature | Vol 577 | 16 January 2020 Article (CSP3 (AGAP008055) and CSP5 (AGAP008058)) and one in the abdo- men carcass (CSP ...

Nature | Vol 577 | 16 January 2020 | 379 of pyrethroid insecticides^6 ,^7 (deltamethrin: CYP6M2, IC 50  = 4.24 μM and CYP6P3, IC ...

380 | Nature | Vol 577 | 16 January 2020 Article the selection statistics—integrated Haplotype Score (his)^20 and XP-EHH (Cross ...

Methods Data reporting No statistical methods were used to predetermine sample size. The experiments were not randomized and the ...

Article with microdissection scissors and tweezers on iced PBS, alongside 5–7 age-matched whole females from the same cage. The ...

equilibration buffer for 15 column volumes. Bound protein was eluted with 5 column volumes of 20 mM Tris, 300 mM NaCl, 500 mM im ...

Article and PCR and associated sequencing experiments. A.A. and G.L. produced the transgenic lines and associated phenotypic cha ...

Extended Data Fig. 1 | Chemosensory protein cluster. a, Schematic of the region surrounding the shared haplotype block found in ...

Article Extended Data Fig. 2 | Overexpression of the CSP family in a multi- insecticide-resistant Anopheles population. Left, me ...

Extended Data Fig. 3 | Expression levels of non-induced chemosensory proteins after exposure to deltamethrin in Tiassalé mosquit ...

Article Extended Data Fig. 4 | Eff icacy of RNAi. mRNA knockdown of whole female mosquitoes 72 h after injection compared with G ...

Extended Data Fig. 5 | Phenotype of other induced CSPs to a panel of insecticides. a, Effect of attenuation of dsSAP3 on mortali ...

Article Extended Data Fig. 6 | Characterization of SAP2 in the transgenic line. a, Mean mRNA expression after SAP2 overexpressio ...

Extended Data Fig. 7 | Effect of SAP2 RNAi injection on the f itness of Tiassalé mosquitoes. a, Longevity of SAP2 RNAi (dsSAP2)- ...

Article Extended Data Fig. 8 | Mortality of A. coluzzii field populations. Temporal plot of mortality from 2011 to 2018 of A. co ...

Extended Data Fig. 9 | Sequencing of SAP2 primer binding sites. Four N’Gousso and four Tiassale mosquitoes were sequenced across ...

Article Extended Data Table 1 | Expression of the CSP family in western Africa Microarray fold-change data from microarray datas ...

1 nature research | reporting summary October 2018 Corresponding author(s): Hilary Ranson Victoria A Ingham Last updated by auth ...

2 nature research | reporting summary October 2018 Field-specific reporting Please select the one below that is the best fit for ...

Nature | Vol 577 | 16 January 2020 | 381 Article Last appearance of Homo erectus at Ngandong, Java, 117,000–108,000 years ago Ya ...