Nature - USA (2020-01-23)
Nature | Vol 577 | 23 January 2020 | 565 effect of the TLS signature using previously published^27 data from an additional cohor ...
Article Methods No statistical methods were used to predetermine sample size. The experiments were not randomized and investigat ...
normalization was applied. As the data was still affected by degrada- tion, PC1 and PC2 of the data were removed using R package ...
Article Extended Data Fig. 1 | Characterization of TLSs in melanoma tumours. a, CD20 (B cells), CD3 (T cells), CD8 (CD8+ T cells ...
Extended Data Fig. 2 | High-plex proteomic analysis using the GeoMx assay and genomic characterization of tumours containing TLS ...
Article % IGHD of B−cells Non−responderResponder IGHD P = 0.19 % IGHG of B−cells ...
Extended Data Fig. 4 | Comparison of the derived TLS gene signature to other immune signatures. a, Pearson correlation plots of ...
Article Extended Data Fig. 5 | TLS gene signature in cohorts treated by ICB. a, Progression-free survival (PFS) and TLS gene sig ...
Extended Data Table 1 | Clinical features of the 177-patient cohort, shown in correlation with CD8/CD20 immunological grouping P ...
Article Extended Data Table 2 | Univariate and multivariate Cox regression model analysis of immunological groupings in melanoma ...
Extended Data Table 3 | Immune-related proteins investigated in the GeoMx analysis ...
Article Extended Data Table 4 | SAM analysis results to obtain the nine-gene TLS signature *Gene unique to the tumours with TLS. ...
Extended Data Table 5 | Clinical features of the cohorts treated by ICB ...
1 nature research | reporting summary October 2018 Corresponding author(s): Göran Jönsson Last updated by author(s):Nov 7, 2019 ...
2 nature research | reporting summary October 2018 Data Policy information about availability of data All manuscripts must inclu ...
3 nature research | reporting summary October 2018 molecular weights for CD3 antigens. The antibody recognizes CD3e in both a T- ...
566 | Nature | Vol 577 | 23 January 2020 Article TGF-β orchestrates fibrogenic and developmental EMTs via the RAS effector RREB1 ...
Nature | Vol 577 | 23 January 2020 | 567 RREB1 as a RAS-regulated SMAD cofactor TGF-β binding to the receptor kinases TGFBR1 and ...
568 | Nature | Vol 577 | 23 January 2020 Article The induction of lethal EMT by TGF-β in KRAS-mutant pancreatic progenitor cells ...
Nature | Vol 577 | 23 January 2020 | 569 indicating that RREB1 is required for TGF-β-induced EMT in normal mammary epithelial ce ...
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