Science - 06.03.2020

sequence) (fig. S10). However, the noncanonical CDSs, on average, have lower PhyloCSF scores compared with canonical proteins (f ...

Chenet al.,Science 367 , 1140–1146 (2020) 6 March 2020 5of7 Fig. 4. Bicistronic mRNAs can encode uORF peptides that function in ...

both a fluorescent reporter to detect stable expression and cellular localization and a handle for coimmunoprecipitation (co-IP) ...

S. R. Starcket al.,Science 351 , aad3867 (2016). N. T. Ingoliaet al.,Cell Rep. 8 , 1365–1379 (2014). N.T.Ingolia,L.F.Lareau,J.S ...

MICROBIOLOGY PE/PPE proteins mediate nutrient transport across the outer membrane ofMycobacterium tuberculosis Qinglan Wang^1 , ...

and numerous, they are commonly thought to play a role in interacting with the human im- mune system ( 12 ). However, these prot ...

sources (fig. S1, D and E). Uptake assays for (^14) C-glycerol and (^14) C-glucose showed that the mutant was deficient because ...

this locus, as well as the entireppe25-pe19 locus, noting the high sequence identity be- tweenppe25andppe27genes (86.2%) and pe1 ...

a lack of transport of PE19. The phylogeny and distribution of the PE/PPE proteins is such that all slow-growing mycobacteria se ...

TRANSCRIPTION Sequencing metabolically labeled transcripts in single cells reveals mRNA turnover strategies Nico Battich, Joep B ...

time points and fittedkandgusing the non– steady-state model (Fig. 2B and fig. S8) on 528 genes that showed high expression chan ...

predict the dynamic range and the expression timing of our CEL-seq2 dataset. However, when either rate was assumed constant, we ...

Battichet al.,Science 367 , 1151–1156 (2020) 6 March 2020 4of5 umap 1 umap 2 Lgr5-GFP Enterocytes Tuft cells Paneth cells Stem c ...

transcript(Fig.3,BandD).Weclustered single-cell expression levels using SOMs and identified stem cells (clusters 8 and 11), full ...

new products SCIENCE sciencemag.org/custom-publishing 6 MARCH 2020 • VOL 367 ISSUE 6482 1157 Produced by the Science/AAAS Custom ...

ARL Distinguished Postdoctoral Fellowships The Army Research Laboratory (ARL) Distinguished Postdoctoral Fellowships provide opp ...

online @sciencecareers.org focus on diversity and inclusion FacultyPositioninHost-PathogenInteractionsandMicrobialImmunology Dep ...

KEK HIGHENERGYACCELERATOR RESEARCHORGANIZATION Call forNominationforNextDirectorGeneralofKEK KEK,HighEnergyAcceleratorResearchOr ...

HIGH-LEVEL GLOBALTALENTS RECRUITMENT Welcome back to hometown. Thousands of academic job vacancies are in fast-developing China. ...

When I first heard about the improv classes, I was torn. As an introvert, I feared getting on stage and impro- vising in front o ...