Science - 06.03.2020

cells under four conditions: control culture or a culture with BMP2, RA, or both BMP2 and RA.Zglp1was undetectable in the contro ...

We examined the consequences of ZGLP1 overexpression in a culture lacking fetal bovine serum and including WIN18,446, an inhibit ...

be up-regulated inZglp1−/−cells, were mainly associated with the processes for the meiotic prophase such as“synapsis”and“meiotic ...

Nagaokaet al.,Science 367 , eaaw4115 (2020) 6 March 2020 6of9 A C F GH DE B Fig. 4. Regulatory coverages of ZGLP1 and STRA8 for ...

ZGLP1 from c3 onward without or with RA (fig. S12, A to C, and tables S4 and S5), and analyzed them with reference to the chroma ...

and at c5 than those not bound by ZGLP1, whereas the H3K4me3-enriched genes were up-regulated similarly irrespective of the ZGLP ...

D. L. Pittmanet al., Meiotic prophase arrest with failure of chromosome synapsis in mice deficient for Dmc1, a germline-specifi ...

RESEARCH ARTICLE SUMMARY ◥ INTEGRATIVE OMICS An atlas of the protein-coding genes in the human, pig, and mouse brain Evelina Sjö ...

RESEARCH ARTICLE ◥ INTEGRATIVE OMICS An atlas of the protein-coding genes in the human, pig, and mouse brain Evelina Sjöstedt1,2 ...

compared with other brain regions. No bias between the different platforms for transcrip- tomics analysis (HPA, GTEx, and FANTOM ...

of all the protein-coding genes. The results for each of the three mammalian brains are shown in Fig. 2, D to F, with details in ...

the IF data indicate a distinct neuronal ex- pression of NECAB1 in subsets of neurons in various regions of the thalamus and for ...

more extended pig and rodent olfactory sys- tems, which have olfactory bulbs that are larger than the more rudimentary human olf ...

are essential for differentiation and mainte- nance of cell identities in the postmitotic brain ( 29 ); (ii) cell identity genes ...

(Fig. 5B). Notably, NEUROD1 is also expressed in retina of mouse and pig but not human (see gene-specific page of HPA Brain Atla ...

These GPCRs include many olfactory recep- tors with highest mRNA levels in the olfac- tory bulb, possibly located in the axons o ...

and fig. S35), while many astrocyte and microglia genes are classified as elevated in other tissues. In fact, several astrocyte ...

Sjöstedtet al.,Science 367 , eaay5947 (2020) 6 March 2020 10 of 16 ENPP6 Oligodendrocyte SLC13A5 Astrocyte ALDH1L1 ALOX5 Microgl ...

and hepatocytes in the metabolism of secreted substrates. We subsequently analyzed the signature genes for oligodendrocytes. Exp ...

and experiments were conducted in line with European directives and regulations. Wild-typemale(n=2)andfemale(n=2) C57BL/6J mice ...