Science - USA (2020-03-13)

1206-B 13 MARCH 2020 • VOL 367 ISSUE 6483 sciencemag.org SCIENCE PHOTO: JOYDEEP BHADURY INSIGHTS REGENERATIVE MEDICINE Hope for ...

SCIENCE sciencemag.org 13 MARCH 2020 • VOL 367 ISSUE 6483 1206-B STEPS TOWARD STABLE EX VIVO HSC EXPANSION To test this hypothes ...

PHOTO: FRANCESCO TOMASINELLI/SCIENCE SOURCE; GRAPHIC: WRAPP ET AL . SCIENCE sciencemag.org 13 MARCH 2020 • VOL 367 ISSUE 6483 12 ...

1208 13 MARCH 2020 • VOL 367 ISSUE 6483 sciencemag.org SCIENCE RESEARCH | IN SCIENCE JOURNALS that memory can persist are unknow ...

POLYMER SCIENCE Tying together common plastics Two challenges to overcome when recycling postconsumer waste are the need to sort ...

1209-B 13 MARCH 2020 • VOL 367 ISSUE 6483 sciencemag.org SCIENCE RESEARCH MEDICINE New therapies for sickle cell disease Sickle ...

SCIENCE sciencemag.org 13 MARCH 2020 • VOL 367 ISSUE 6483 1209-C messenger RNA deadenylation and degradation are important proce ...

RESEARCH ARTICLE SUMMARY ◥ CELL BIOLOGY Liquid-liquid phase separation drives skin barrier formation Felipe Garcia Quiroz, Vince ...

RESEARCH ARTICLE ◥ CELL BIOLOGY Liquid-liquid phase separation drives skin barrier formation Felipe Garcia Quiroz^1 *, Vincent F ...

tagged-FLG variants, although the results were consistent independent of the tag (fig. S7, G and H). To further explore whether ...

we performed serial force-indentation measure- ments across the granule length in HaCATs harboring different filaggrin variants ...

evaluate the liquid-like behavior of KGs formed from different-sized filaggrin mutants. As pre- dicted, KGs assembled from trunc ...

additional facets of terminal differentiation might be contributing to this puzzling behav- ior. Notably, the granular layer als ...

As granular cells moveupward to complete their final stage of differentiation, they enucleate andlosetheirKGstoformflattenedsqua ...

enucleation events in skin are likely driven by a combination of nuclear deformation and pH-driven release of as yet undetermine ...

physically distort adjacent organelles prior to the ensuing environmental stimuli that trigger KG disassembly. Overall, the envi ...

media, CnT-PR-D (CELLnTEC, Switzerland) supplemented with 1.5 mM CaCl 2 and proceeded to use a spinning-disk confocal microscope ...

porous membrane (Whatman Nuclepore Track- Etched Membranes, 13-mm diameter, 5-mm pores) and a 12-mm cover glass (Fisherbrand). O ...

M. Fericet al., Coexisting liquid phases underlie nucleolar subcompartments.Cell 165 , 1686–1697 (2016). doi:10.1016/j.cell.201 ...

V.F.F. conceived and performed AFM experiments. J.L. performed lentiviral injections.L.P. established and maintained all relevan ...