Science - USA (2020-03-13)

a simplistic model, we speculate that dimeric RTX:CD20 building blocks (Fig. 1C) can assem- ble into a 3-to-3 closed-ring config ...

T. Ramaraj, T. Angel, E. A. Dratz, A. J. Jesaitis, B. Mumey, Biochim. Biophys. Acta. 1824 , 520–532 (2012). D. Ugurlaret al.,Sc ...

REPORT ◥ FUNCTIONAL AMYLOIDS Cryo-EM structure of a neuronal functional amyloid implicated in memory persistence inDrosophila Ru ...

filament is composed of three identical proto- filaments related by C3 symmetry with sep- aratedb-strands along the helical axis ...

likely correspond to the RNA-recognition motif and protein interaction domain of Orb2 (Fig. 4C, gray density). We could identify ...

additional nonproteinaceous density that runs contiguously across therungs(Fig.4D,red arrows, and fig. S10D). This density is co ...

Moreover, removal of 54 amino acids from the glutamine-rich region specifically interfered with long-term, but not short-term, m ...

GLACIAL CYCLES Persistent influence of obliquity on ice age terminations since the Middle Pleistocene transition Petra Bajo1,2,3 ...

speleothems, thed^18 O of planktic foraminif- era from the Iberian margin and the western Mediterranean Sea is also sensitive to ...

( 18 ),resultinginstrongNorthernHemisphere (NH) summer insolation and a very rapid ter- mination,whereasthemoreprolongedTX start ...

for each one to run to completion ( 18 ). We find that duration is significantly correlated with caloric summer half-year energy ...

with peaks in an insolation forcing metric (almost identical to caloric summer half-year insolation at 65°N), which integrates a ...

STRUCTURAL BIOLOGY Structure of V-ATPase from the mammalian brain Yazan M. Abbas^1 ,DiWu^2 , Stephanie A. Bueler^1 , Carol V. Ro ...

even with two copies of C1 (Fig. 1C, blue), the latter possibly attributable to the loss of sub- unit H. The enzyme preparation ...

yeast V 1 (-C) complex ( 27 ).Thesemapsonlyal- lowed visualization ofahelices in the structure. ThecurrentstructureoftheV 1 regi ...

contains nine copies of subunit c and one of subunit c′′(Fig. 3B, pink and purple). As ex- pected from the lack of a homologous ...

in V-ATPase activity, RNAseK is necessary for viral endocytosis and replication ( 22 , 43 ). The cryo-EM density for subunit f, ...

Ac45 appears as a single low-resolution domain approximately 30 Å by 20 Å by 30 Å in size (Fig. 4C, light blue), which is consis ...

proteomics and native mass spectrometry experiments and C.V.R. supervised the mass spectrometry. J.L.R. and Y.M.A. wrote the man ...

ORGANIC CHEMISTRY Enantioselective remote C–H activation directed by a chiral cation Georgi R. Genov, James L. Douthwaite, Antti ...