Nature 2020 01 30 Part.02

Article Extended Data Fig. 4 | Two-way hierarchical clustering of scaled data from Fig.  2. a, Dendrogram showing two-way hierar ...

Extended Data Fig. 5 | See next page for caption. ...

Article Extended Data Fig. 5 | Isoproterenol-induced change in Rad detected by mass spectrometry. a, Right, the MS^2 spectrum (t ...

Extended Data Fig. 6 | Rad is required for forskolin-induced activation of heterologously expressed CaV1.2 channels. a, Exemplar ...

Article Extended Data Fig. 7 | PKA phosphorylation sites in mouse Rad. a, Serine/ threonine residues (in purple) that are mutate ...

Extended Data Fig. 8 | Binding of Rad and β2B is required for regulation of forskolin-induced stimulation of voltage-gated Ca2+ ...

Article Extended Data Fig. 9 | Phosphorylation-dependent dissociation of Rad, β 3 and β 4 subunits. a, b, FRET two-hybrid bindin ...

Extended Data Fig. 10 | ClustalW alignment of Rad sequences and RGK GTPases. a, Conservation of phosphorylation sites from mouse ...

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Nature | Vol 577 | 30 January 2020 | 701 Article Negative supercoil at gene boundaries modulates gene topology Yathish Jagadhees ...

702 | Nature | Vol 577 | 30 January 2020 Article We compared the supercoil context at intergenic spaces with respect to gene ori ...

Nature | Vol 577 | 30 January 2020 | 703 mutants behaved similarly to hmo1Δ cells (Extended Data Fig. 4f, g). Hence, ablation of ...

704 | Nature | Vol 577 | 30 January 2020 Article in clusters, with 31% of loops containing more than one gene and 51% of loops c ...

Nature | Vol 577 | 30 January 2020 | 705 Bermejo, R., Lai, M. S. & Foiani, M. Preventing replication stress to maintain gen ...

Article Methods Strains and growing conditions All S. cerevisiae strains are W303 derivatives^46. The relevant genotypes are sho ...

Library Preparation Kit for Ion Torrent (KAPA Biosystems) and adap- tor barcode Kapa Barcode Adaptors 9-24. After adaptor ligati ...

Article i = (1, 2, 3 ... total genes), yi is the end position of the ith gene, i = (1, 2, 3 ... total genes), Z is base position ...

Extended Data Fig. 1 | See next page for caption. ...