Science 31Jan2020

sciencemag.org SCIENCE RESEARCH NEUROSCIENCE A learning mechanism in the striatum An intriguing characteristic of the striatum i ...

RESEARCH SCIENCE sciencemag.org tagged with a fluorescent label (see the Perspective by Paxton). This dsRNA module can be target ...

REVIEW SUMMARY ◥ CANCER IMMUNOTHERAPY Neoadjuvant checkpoint blockade for cancer immunotherapy Suzanne L. Topalian*, Janis M. Ta ...

REVIEW ◥ CANCER IMMUNOTHERAPY Neoadjuvant checkpoint blockade for cancer immunotherapy Suzanne L. Topalian1,2*, Janis M. Taube2, ...

either before surgical removal of the primary tumor (neoadjuvant) or afterward (adjuvant). Survival was significantly better wit ...

The trafficking of DCs carrying tumor antigen to TDLN was also demonstrated by Salmonet al.( 40 ). They provided experimen- tal ...

responses (defined as≥30% decrease in the sum of tumor diameters) were observed in only 2 of 21 (10%) patients, major pathologic ...

posttreatment increases in the peripheral blood of clones that were highly represented in pre- treatment tumor biopsies, further ...

≤50% RVT), or“no pathologic response”(>50% RVT) ( 64 ), whereas others focused only on pCR as a readout (Table 1). A study of ...

chemokines or even synthetic scaffolds to in- duce TLS formation in otherwise“noninflamed” tumors ( 69 ). High expression of gen ...

C. E. Rudd, A. Taylor, H. Schneider, CD28 and CTLA-4 coreceptor expression and signal transduction.Immunol. Rev. 229 ,12–26 (20 ...

(pbo) + chemo as neoadjuvant treatment, followed by pembro vs pbo as adjuvant treatment for early triple-negative breast cancer ...

RESEARCH ARTICLE SUMMARY ◥ NEUROSCIENCE Monosomes actively translate synaptic mRNAs in neuronal processes Anne Biever, Caspar Gl ...

RESEARCH ARTICLE ◥ NEUROSCIENCE Monosomes actively translate synaptic mRNAs in neuronal processes Anne Biever^1 , Caspar Glock^1 ...

statistics shown in fig. S3A), the classical ribosome profiling quality metrics were as- sessed (fig. S3). As expected, the mono ...

and methods) in the monosome and poly- some footprint libraries. Using differential expression analysis ( 18 ), we identified lo ...

that a large proportion of transcripts prefer thesametypeofribosomeoccupancyinboth compartments (Fig. 5A, monosome-enriched in q ...

see fig. S14B for the somata). Around half of the 326 proteins encoded by monosome- preferring transcripts exhibited protein abu ...

have been reported to move within cells at an average speed of 2mm/s ( 53 ), and poten- tially greater mobility of translating m ...

protein production for long ORFs ( 58 – 60 ). In part, this observation can be explained by reduced initiation rates of longer t ...