Science 31Jan2020

Liuet al.,Science 367 , 580–586 (2020) 31 January 2020 5of6 A -1.00 -0.67 -0.33 0.00 0.33 0.67 1.00 -3.00 -2.00 -1.00 0.00 1.00 ...

downstream gene transcription, and elevated local H3K4me3 and H3K27ac levels (Fig. 4J and fig. S18). Together, these results str ...

CANCER Therapeutic targeting of preleukemia cells in a mouse model ofNPM1mutant acute myeloid leukemia Hannah J. Uckelmann1,2, S ...

thatNpm1cmutant LT-GMPs may acquire fur- ther mutations over time, which has been shown to occur in this and otherNpm1cknock-in ...

to target the oncogenic MLL-fusion complexes by directly disrupting the oncogene complex from assembling on chromatin. Our findi ...

disruption showed no or only minor effects onHOXandMEIS1(Fig. 3F and fig. S8E). In agreement with this,MeninandMLL1KO cells were ...

(hCD45)] (fig. S13A). A reduction of blood leukemia burden was observed after 3 weeks of VTP-50469 treatment. Except for one mou ...

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Avoiding immigration limbo B anks won’t give a mortgage loan to someone who is only going to be in the country for 1 year,” decl ...