Science - 06.12.2019

syndromes that confer only a minimal predis- position to Wilms tumor ( 11 ). We did not find any further driver events accountin ...

1A). Accordingly, cancers may arise either di- rectly in isolation through LOH of 11p15, or indirectly via clonal nephrogenesis ...

(R.A.-S., K.P.-J.), and Li Ka Shing foundation (D.C.W.). J.D. acknowledges funding from the Alpe d’HuZes foundation/KWF Dutch Ca ...

HUMAN RETINA Functional diversity of human intrinsically photosensitive retinal ganglion cells Ludovic S. Mure^1 , Frans Vinberg ...

and D), supporting the notion that the intrinsic photosensitivity is mediated by melanopsin. Next, we tested whether human ipRGC ...

retinas, 11-cis-retinal–dependent mouse ipRGCs formed a distinct cluster (fig. S4B). These cells displayed response characterist ...

It has long been assumed that the primary function of ipRGCs is to count photons ( 14 ). Our results both confirm and expand thi ...

BIOCATALYSIS Design of an in vitro biocatalytic cascade for the manufacture of islatravir Mark A. Huffman^1 , Anna Fryszkowska^1 ...

the tandem forward reaction from sugar 5- phosphate ( 4 ), with the 1-phosphate ( 3 )being generated in situ by the newly evolve ...

acetyl phosphate as an economical source of activated phosphate paired with a thermo- stable acetate kinase (AcK) fromThermotoga ...

undesired side reactionscatalyzed by host-cell enzymes. Immobilization was not pursued for the aldol and glycosylation enzymes b ...

and enzyme evolution. A.R.-G, E.C.S., D.V., and L.X. carried out computational work to support enzyme discovery and evolution. C ...

STRUCTURAL BIOLOGY Structures of the AMPA receptor in complex with its auxiliary subunit cornichon Terunaga Nakagawa In the brai ...

Ctermini(Fig.2,AandB).CNIH3lacksa canonical signal peptide, but the N terminus, which remains uncleaved and buried in the membra ...

aligned at an RMSD of 0.763 Å (Fig. 2D). The detailed residue contacts are different (see the supplementary text and fig. S16), ...

the complex and bidirectionally alters the magnitude of gating modulation by CNIH3 ( 26 ). Replacing A793 of M4 and F3 of CNIH3 ...

Y. Shiet al.,Proc. Natl. Acad. Sci. U.S.A. 107 ,16315–16319 (2010). J. Trayneliset al.,Genome Res. 27 , 1715–1729 (2017). E. C. ...

TRILLIONS OF MICROBES ONE ESSAY Apply by 1/24/20 at http://www.sciencemag.org/noster Sponsored by NOSTER Bio-Institute, Nitto Ph ...

The science ofbeing a scientist Throughout 2019,Science and Fondation Ipsen are ofering free Science and Life webinars that tack ...

One or more of these products are covered by patents, trademarks and/or copyrights owned or controlled by New England Biolabs, I ...