The scientist --life inspiring innovation muscle bound

09.2018 | THE SCIENTIST 39 version, but it can direct the removal of problematic portions of it. And there is good reason to thi ...

40 THE SCIENTIST | the-scientist.com © STEVE GRAEPEL THE GENETICS OF DUCHENNE Duchenne muscular dystrophy results from mutations ...

09.2018 | THE SCIENTIST 41 immune reactivity against the bacterial Cas9 protein or the viral vector, for example. Preexisting im ...

CREDIT LINECREDIT LINE 42 THE SCIENTIST | the-scientist.com CREDIT LINE ...

09.2018 | THE SCIENTIST 43 MODIFIED FROM © ISTOCK.COM, PARA-GRAPH, GREENVECTOR I n the early 2000s, Stefano Schiaffino, a muscle ...

44 THE SCIENTIST | the-scientist.com © ISTOCK.COM, VUKOSLAVOVIC such as diabetes. Research also indicates that these clocks may ...

mal—after a meal, for example. In fact, skeletal muscle is the body’s major glucose storage unit, responsible for around 70 perc ...

46 THE SCIENTIST | the-scientist.com THE SCIENTIST STAFF “But what happens in type 2 diabetes is still a remaining ques- tion in ...

09.2018 | THE SCIENTIST 47 MODIFIED FROM © ISTOCK.COM, DARUMO role. A recent study by Bass and his colleagues at Northwest- ern ...

48 THE SCIENTIST | the-scientist.com © ISTOCK.COM, CHRISCHRISW T o you readers over age 30, we’ve got some bad news for you. Cha ...

09.2018 | THE SCIENTIST 49 CREDIT LINECREDIT LINE 09.2018 | THE SCIENTIST 49 CREDIT LINECREDIT LINECREDIT LINE ...

50 THE SCIENTIST | the-scientist.com lated from a two-year-old rat was repaired faster and better when grafted into two- to thre ...

09.2018 | THE SCIENTIST 51 © SCOTT LEIGHTON MUSCLE STEM CELLS Muscle stem cells, or satellite cells, decrease in number as we ag ...

cle physiology and repair, or they can have effects in distant organs, such as the brain. Although several of these myokines hav ...

09.2018 | THE SCIENTIST 53 els comparable to those observed in young subjects. Additionally, exercise improved muscle function: ...

THE PAPER A.S. Smith et al., “Myosin IIA interacts with the spectrin-actin membrane skeleton to control red blood cell membrane ...

09.2018 | THE SCIENTIST 55 © ISTOCK.COM, ALVAREZ; © ISTOCK.COM, UNOL MUSCLED UP: In mice, it’s not just the brain that influence ...

56 THE SCIENTIST | the-scientist.com PROFILE CHRIS THEKKEDAM F or Angela Dulhunty, the main draw of studying cells’ electri- cal ...

09.2018 | THE SCIENTIST 57 ANGELA DULHUNTY Emeritus Professor, John Curtin School of Medical Research, Australian National Unive ...

58 THE SCIENTIST | the-scientist.com PROFILE tiny indented structures in the surface membrane of individual muscles that are als ...