Nature - USA (2020-06-25)

586 | Nature | Vol 582 | 25 June 2020 Article Oncometabolites suppress DNA repair by disrupting local chromatin signalling Parke ...

Nature | Vol 582 | 25 June 2020 | 587 treatment, and with or without treatment with the mutant IDH1- or IDH2-specific inhibitors ...

588 | Nature | Vol 582 | 25 June 2020 Article ionizing radiation (Extended Data Fig. 6i). We also found a defect in phosphorylat ...

Nature | Vol 582 | 25 June 2020 | 589 Consistent with the data from the YUNK1 cells, knockdown of KDM4B, but not KDM4A, increase ...

590 | Nature | Vol 582 | 25 June 2020 Article PARP inhibition (Extended Data Fig. 10w), but it did not have any further effect o ...

Nature | Vol 582 | 25 June 2020 | 591 Xu, W. et al. Oncometabolite 2-hydroxyglutarate is a competitive inhibitor of α-ketogluta ...

Article Reporting summary Further information on research design is available in the Nature Research Reporting Summary linked to ...

Extended Data Fig. 1 | See next page for caption. ...

Article Extended Data Fig. 1 | Elevated oncometabolites induce H3K9me3 and inf luence global gene expression, but do not alter e ...

Extended Data Fig. 2 | See next page for caption. ...

Article Extended Data Fig. 2 | Oncometabolites directly impair formation of R AD51 and BRCA1 foci after ionizing radiation and c ...

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Article Extended Data Fig. 3 | Supporting data for DSB–ChIP assays to analyse recruitment of DNA repair factors to an I-SceI-ind ...

Extended Data Fig. 4 | See next page for caption. ...

Article Extended Data Fig. 4 | Elevated metabolites have minimal effects on cell cycle distribution, growth rates and NHEJ DNA r ...

Extended Data Fig. 5 | See next page for caption. ...

Article Extended Data Fig. 5 | Elevated metabolites disrupt normal H3K9me3 deposition at sites of DNA damage caused by laser-str ...

Extended Data Fig. 6 | See next page for caption. ...

Article Extended Data Fig. 6 | Oncometabolites impair TIP60 and ATM recruitment and activation following treatment of cells with ...

Extended Data Fig. 7 | See next page for caption. ...