Article
Extended Data Fig. 8 | IV BCG protects against extrapulmonary disease
and lung infection across a wide range of thresholds of protection.
a, Extrapulmonary disease was scored at necropsy based on a published
system^27 taking into account the presence of Mtb-related pathology and Mtb
growth from sites outside the thoracic cavity. Each symbol represents an
animal and horizontal bars represent the median. Kruskal–Wallis tests were
used and reported P values represent Dunn’s multiple comparison test
comparing each group to IDlow. All data points within the grey areas are zero.
There was no extrapulmonary disease in any of the IV-BCG-vaccinated
macaques, whereas the other groups had variable extrapulmonary
involvement. b, Fisher’s exact test P values are plotted for a range of CFU
thresholds evaluating protection. For each threshold, a stacked bar plot
indicates the percentage of NHPs with fewer CFUs than the threshold (that is,
protected), in each vaccine group. Immunization route significantly (P < 10−4)
impacted protection at any given CFU threshold between <1 (sterile) and <10^4.