Science - USA (2020 09 04)
significantly delayed tail regeneration in ho- mozygous mutants compared with wild-type animals (Fig. 4G and fig. S17, A and B). ...
most enriched motif in all analyses performed (Fig. 6, A and B, and fig. S19, A to C). Similarly, AP-1 motifs were enriched in t ...
that different cell populations may form dis- tinct AP-1 complexes. Further, genome-wide prediction of AP-1 motifs among differe ...
tail regeneration (fig. S20, F and G). We con- clude that AP-1 motifs are required for the activation of RREs in response to amp ...
These studies demonstrated that regulatory elements in orthologous loci were functionally active in distinct tissues, indicating ...
RESEARCH ARTICLE SUMMARY ◥ NEUROSCIENCE Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neur ...
RESEARCH ARTICLE ◥ NEUROSCIENCE Regulation of sleep homeostasis mediator adenosine by basal forebrain glutamatergic neurons Wanl ...
nonbinding mutant form of the adenosine sen- sor (fig. S6 and Fig. 2D; Wake versus NREM: P= 0.08; REM versus NREM:P= 0.94). Bene ...
observed changes in extracellular adenosine during the sleep-wake cycle. However, the am- plitude of evoked adenosine changes wa ...
sleep, as compared to control mice (Fig. 4, K and L; VGLUT2 lesion versus no-lesion, Wake (normalizedDF/F 0 ,norm.z-score): 1.6 ...
measured during the subsequent 18 hours (Fig. 5D and fig. S15) ( 39 ). Although both lesion and control mice showed compensatory ...
contribution to the sleep-wake regulation by different wake-active neurons in the BF. The long delay in the increase of extracel ...
Statistics A normality test was first performed on each dataset using the Shapiro-Wilk test. The para- metric tests were used if ...
RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic ...
RESEARCH ARTICLE ◥ CORONAVIRUS Deep immune profiling of COVID-19 patients reveals distinct immunotypes with therapeutic implicat ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 2of17 Fig. 1. Clinical characterization of patient cohorts, inflamma ...
University of Pennsylvania (UPenn IRB 808542) that included 149 adults with confirmed SARS- CoV-2 infection (i.e., COVID-19 pati ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 4of17 Fig. 2. CD8 T cell subset skewing and activation patterns in C ...
and CD38 coexpression that was signifi- cantly increased for all non-naïve CD8 T cell subsets (Fig. 2F and fig. S2C). However, t ...
Mathewet al.,Science 369 , eabc8511 (2020) 4 September 2020 6of17 RESEARCH | RESEARCH ARTICLE ...
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