Science - USA (2020 09 04)
of the proinflammatory cytokines IL-6, TNF-a, and IL-1bproduced by monocytes and mDCs upon TLR stimulation (Fig. 2B). This was c ...
bulk transcriptomics data are publicly available in the Gene Expression Omnibus (GEO) under accession numbers GSE155673 and GSE1 ...
STRUCTURAL BIOLOGY Structure of a human 48Stranslational initiation complex Jailson Brito Querido^1 , Masaaki Sokabe^2 , Sebasti ...
18 Sribosomal RNA (rRNA) and ribosomal proteins (r-proteins) and rationalize previous biochemical data ( 17 , 18 ). The subunits ...
near the exit site (Fig. 2B and table S2). The structure also reveals the basis of the interac- tion of eIF3a and eIF3c with r-p ...
eIF3g binds at the mRNA entry site eIF3g contains an RNA-recognition motif (eIF3g-RRM) that is thought to enhance scan- ning eff ...
occurs after splitting ( 20 , 29 ) would prevent a steric clash with eIF3j (fig. S14). Thus, eIF3j is likely to be recruited aft ...
subunits such as the eIF3d-NTT and eIF3e, which has been previously suggested by bio- chemical cross-linking ( 4 ). eIF4A binds ...
of 30, 19, or 10 nucleotides. This blind spot is consistent with the fact that leaky scanning is observed on mRNAs that contain ...
characterized the complex, prepared cryo-EM grids, and performed the cryo-EM analysis. J.B.Q., Y.G., S.K., and V.R. interpreted ...
PROTEIN DESIGN A defined structural unit enables de novo design of small-molecule–binding proteins Nicholas F. Polizziand Willia ...
(figs. S3 and S4), only a small fraction of vdMs are highly enriched in protein struc- tures (C>0).Forexample,only91AspCONH 2 ...
on the CONH 2 of a vdM, uniquely defining the position of apixaban in the binding site. Apixaban’s conformation in this step was ...
Superimposing by all heavy atoms of core amino acids, including apixaban, gives an RMSD of 0.98 Å. ABLE buries almost all avail- ...
packing, they instead adopt their preferred rotamers. The structure illustrates that glo- bal packing of core residues supports ...
which has higher b-factors and two alter- nate conformations (related by a 180° ring flip) in the structure (fig. S16). Thus, ba ...
A. Lombardi, F. Pirro, O. Maglio, M. Chino, W. F. DeGrado, Acc. Chem. Res. 52 ,1148–1159 (2019). J. R. Desjarlais, T. M. Handel ...
REPORT ◥ STELLAR ASTROPHYSICS A triple-star system with a misaligned and warped circumstellar disk shaped by disk tearing Stefan ...
scattered light. On the basis of hydrodynamic simulations [for example, ( 4 , 22 )] and the detection of lower-density dust betw ...
suggesting that this disk region is susceptible to disk tearing ( 16 ). We used the observational constraints on the orbital par ...
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