Science - USA (2020-10-02)
REVIEW Translating genetic risk of Alzheimer’s disease into mechanistic insight and drug targets Annerieke Sierksma1,2, Valentin ...
As indicated by the broad confidence intervals, the AD heritability estimates remain imprecise, as with many polygenetic disorde ...
with genes involved in Abgeneration. Next to the fully penetrantAPPandPSENmutations, APPgene duplications and triplications, in- ...
andABI3(Abelson interactor family protein 3), which are genes mainly or exclusively expressed in myeloid cells, also point in th ...
integrator-1 and amphiphysin-2) enhancer, which carries one of the higher AD risk var- iants, rs6733839 (OR = 1.2) ( 12 , 50 ). ...
T. S. Wingo, J. J. Lah, A. I. Levey, D. J. Cutler,Arch. Neurol. 69 , 59 – 64 (2012). R. E. Tanzi, L. Bertram,Cell 120 , 545–555 ...
been found to modulate lipid metabolism, lysosomal pathways, and microglial metabolic fitness ( 3 , 17 – 23 ). How microglia may ...
in ameliorating neuronal hyperactivity–induced lipid toxicity ( 20 ). It will be interesting to elu- cidate the relationship bet ...
actin-remodeling factor WAVE2 to regulate phagocytosis specifically in macrophages ( 69 ). Thus, it will be interesting to asses ...
CREDITS (FROM TOP): WANG ET AL .; JAMES CAVALLINI/SCIENCE SOURCE 70 2 OCTOBER 2020 • VOL 370 ISSUE 6512 sciencemag.org SCIENCE a ...
SCIENCE sciencemag.org 2 OCTOBER 2020 • VOL 370 ISSUE 6512 71 PHOTO: MANAN VATSYAYANA/GETTY IMAGES obtained a very large heat fl ...
72 2 OCTOBER 2020 • VOL 370 ISSUE 6512 sciencemag.org SCIENCE RESEARCH | IN OTHER JOURNALS NPs encapsulated by hexagonal boron n ...
RESEARCH ARTICLE SUMMARY ◥ NEURODEVELOPMENT A latent lineage potential in resident neural stem cells enables spinal cord repair ...
RESEARCH ARTICLE SUMMARY ◥ SOLAR CELLS Vapor-assisted deposition of highly efficient, stable black-phase FAPbI 3 perovskite sola ...
RESEARCH ARTICLES ◥ MUTATION Extensive heterogeneity in somatic mutation and selection in the human bladder Andrew R. J. Lawson^ ...
CDKN1A,CREBBP,FOXQ1,RHOA, andERCC2 (Fig. 2A). Using restricted hypothesis testing on known bladder cancer genes and a dN/dS mode ...
in normal urothelium are all known cancer genes. Somatic mutations in certain genes could also lead to cellular death or differ- ...
78 2 OCTOBER 2020•VOL 370 ISSUE 6512 sciencemag.org SCIENCE Fig. 3. Mutation burden and signatures in normal urothelium.(A) Scat ...
differences in selection across individuals. We used a dN/dS-based likelihood ratio test that compares the relative enrichment o ...
a suggestive example of spatial clustering of three APOBEC-positive clones (Fig. 3J). To study the frequency and spatial distrib ...
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