Science - USA (2020-10-02)
and losses of chromosomes 9 and 21 (Fig. 3L). Across 55 genomes of normal urothelium, only 30 rearrangements and three retrotran ...
genetics and a lifetime of different expo- sures. The differences across donors might also raise the possibility of developing p ...
colorectal tissue ( 10 ), liver ( 11 ), endometrial epithelium ( 12 ), bronchial epithelium ( 13 ), brain ( 14 , 15 ), embryonic ...
recurrent CNA regions consistent with TCGA data (e.g., chromosome 5p, 8q, and 3p ampli- fications; and chromosome 8p and 9p dele ...
different between AA-associated and non-AA- associated MNU (Fig. 3A). Mutational burdens in the AA-associated MNU ranged broadly ...
due mainly to two samples, P4U1 and P7U6, while in the non-AA-associated distribution, the peak corresponding to larger clone si ...
larger median mutant clone size (P< 0.001, Wilcoxon rank-sum test), even when we ex- cluded the three samples with drastic cl ...
expansions in MNU; the latter most likely be- cause the mutagenic effects of AA widely cause driver mutations in MNU, facilitati ...
I. Martincorenaet al.,Science 362 , 911–917 (2018). C. Tomasetti, B. Vogelstein, G. Parmigiani,Proc. Natl. Acad. Sci. U.S.A. 11 ...
widely circulating in the general population, and are typically responsible for mild respiratory symptoms ( 14 – 16 ). However, ...
useful in future studies as reagents for track- ing CD4+T cells in SARS-CoV-2–infected indi- viduals and in COVID-19 vaccine tri ...
such as the common cold ( 14 – 16 ). However, there is currently a lack of experimental data addressing whether memory CD4+T cel ...
epitopes derived from other HCoVs, for a total of 124 HCoV homologs (HCoV-S124; table S3). Next, we used an activation-induced m ...
epitope megapools. Results from one represent- ative unexposed donor are shown in Fig. 3A. Responding cells in unexposed donors ...
METALLURGY Multiplicity of dislocation pathways in a refractory multiprincipal element alloy Fulin Wang^1 , Glenn H. Balbus^1 , ...
dislocations to choose the easy gliding di- rection and plane in the random field of multiple atomic species enables an excellen ...
dislocations to glide on various planes may be similar. Dislocations during single-crystal tensile deformation We assessed the d ...
typical bcc metals and close to 2.73 calculated for polycrystalline bcc metals deforming by pencil glide ( 16 ). Therefore, the ...
accurately representing the three-dimensional fluctuation of chemistry. Reminiscent effects have been reported in NiAl hosting t ...
system to be 398 MPa. Compared with the computed LSRs, it is highly likely (at a prob- ability of ~0.8) that the RSS is sufficie ...
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