BNF for Children (BNFC) 2018-2019

lCAUTIONSAvoid intravaginal preparations (particularly those that require use of an applicator) in young girls who are not sexua ...

Chapter 8 Immune system and malignant disease CONTENTS Immune system page 517 1 Immune system disorders and transplantation 517 ...

myelotoxic but markedly nephrotoxic. It may be used in organ and tissue transplantation, for prevention of graft rejection follo ...

SPECIFIC SIDE-EFFECTS ▶With oral useNausea SIDE-EFFECTS, FURTHER INFORMATIONSide-effects may require drug withdrawal. Hypersensi ...

Short-term treatment of very severe atopic dermatitis where conventional therapy ineffective or inappropriate (administered on e ...

Sandimmun®capsules and oral solution are available direct from Novartis for patients who cannot be transferred to a different or ...

lMONITORING REQUIREMENTS ▶Monitor whole blood-sirolimus trough concentration (Afro-Caribbean patients may require higher doses). ...

Prophylaxis of graft rejection following kidney transplantation, starting within 24 hours of transplantation ▶BY MOUTH ▶Neonate: ...

Prophylaxis of graft rejection following heart transplantation without antibody induction, starting within 12 hours of transplan ...

tacrolimus blood trough concentrations much higher than the recommended maximum levels. Patients should be monitored by echocard ...

IMMUNOSUPPRESSANTS›MONOCLONAL ANTIBODIES Canakinumab lDRUG ACTIONCanakinumab is a recombinant human monoclonal antibody that sel ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Powder and solvent for ...

lNATIONAL FUNDING/ACCESS DECISIONS NICE decisions ▶Immunosuppressive therapy for kidney transplant in children and young people ...

lBREAST FEEDINGManufacturer advises avoid during treatment and for at least one month after the last dose— no information availa ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Solution for infusion ...

leucoencephalopathy is suspected, suspend treatment until it has been excluded. lCONCEPTION AND CONTRACEPTIONEffective contracep ...

previous adverse effects to the cytotoxic drug. Doses may also differ depending on whether a drug is used alone or in combinatio ...

an infectious individual with measles, normal immunoglobulin p. 773 should be given. For advice on the use of live vaccines in i ...

lCAUTIONSAvoid in Acute porphyrias p. 603 .high dose (antiepileptic prophylaxis required).history of seizures (antiepileptic pro ...

lBREAST FEEDINGDiscontinue breast-feeding. lHEPATIC IMPAIRMENT Dose adjustmentsManufacturer advises consider dose reduction in s ...