BNF for Children (BNFC) 2018-2019

Antimalarial poisoning Overdosage with quinine, chloroquine, or hydroxychloroquine is extremely hazardous and difficult to treat ...

by increasingfluid intake but avoiding diuretics). Otherwise, treatment is supportive with special regard to electrolyte balance ...

CS spray poisoning CS spray, which is used for riot control, irritates the eyes (hence‘tear gas’) and the respiratory tract; sym ...

Other poisons Consult either the National Poisons Information Service day and night or TOXBASE. TheNational Poisons Information ...

lMEDICINAL FORMS There can be variation in the licensing of different medicines containing the same drug. Forms available from s ...

lHEPATIC IMPAIRMENT Dose adjustmentsCarefully titrate dose. lDIRECTIONS FOR ADMINISTRATIONForcontinuous intravenous infusion, di ...

3.4 Opioid toxicity OPIOID RECEPTOR ANTAGONISTS Naloxone hydrochloride lINDICATIONS AND DOSE Overdosage with opioids ▶BY INTRAVE ...

3.5 Paracetamol toxicity ANTIDOTES AND CHELATORS Acetylcysteine 03-Apr-2018 lINDICATIONS AND DOSE Paracetamol overdosage ▶BY INT ...

to be given over 5 minutes, seek advice from National Poisons Information Service if further repeat doses are required; maximum ...

Appendix Interactions Changes have been made to the interactions content in BNF publications. For more information, seewww.bnf.o ...

Relative importance of interactions Levels of severity:Most interactions have been assigned a severity; this describes the likel ...

TABLE 1 Drugs that cause hepatotoxicity The following is a list of some drugs that cause hepatotoxicity (note that this list is ...

TABLE 6 Drugs that cause bradycardia The following is a list of drugs that cause bradycardia (note that this list is not exhaust ...

TABLE 9 Drugs that prolong the QT interval The following is a list of some drugs that prolong the QT-interval (note that this li ...

TABLE 12 Drugs that cause peripheral neuropathy The following is a list of some drugs that cause peripheral neuropathy (note tha ...

TABLE 16 Drugs that increase serum potassium The following is a list of some drugs that increase serum potassium concentrations ...

List of drug interactions The following is an alphabetical list of drugs and their interactions; to avoid excessive cross-refere ...

Agalsidase ▶Aminoglycosidesare predicted to decrease the effects of agalsidase. Avoid.oTheoretical ▶Antiarrhythmics(amiodarone)a ...

Aldosterone antagonists(continued) ▶Rifampicinis predicted to decrease the exposure to eplerenone. Avoid.oTheoretical ▶St John’s ...

▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are predicted to moderately increase the exposure toalpha blockers ...