BNF for Children (BNFC) 2018-2019

Aminoglycosides→seeTABLE 2p. 847 (nephrotoxicity),TABLE 19 p. 851 (ototoxicity),TABLE 20p. 851 (neuromuscular blocking effects) ...

methaemoglobinaemia when given with topicalprilocaine. Use with caution or avoid.rTheoretical→Also seeTABLE 11 p. 849 ▶Antiepile ...

Antacids(continued) ▶Antacidsare predicted to decrease the absorption ofHIV- protease inhibitors(tipranavir). Separate administr ...

▶Amiodaroneis predicted to slightly increase the concentration ofantiepileptics(fosphenytoin, phenytoin). Monitor and adjust dos ...

Antiarrhythmics(continued) ▶Propafenoneincreases the concentration ofdigoxin. Monitor and adjust dose.rStudy ▶Dipyridamoleincrea ...

▶Dronedaroneis predicted to increase the exposure toopioids (alfentanil, buprenorphine, fentanyl, oxycodone). Monitor and adjust ...

Antiarrhythmics(continued) ▶Dronedaroneis predicted to increase the exposure tovinca alkaloids.rTheoretical→Also seeTABLE 9p. 84 ...

▶Antiepileptics(topiramate)increase the risk of carbamazepine toxicity when given withantiepileptics(carbamazepine). oStudy ▶Ant ...

Antiepileptics(continued) ▶Phenobarbitaldecreases the concentration ofantifungals, azoles(itraconazole). Avoid and for 14 days a ...

▶Capecitabineincreases the concentration ofantiepileptics (fosphenytoin, phenytoin).rAnecdotal ▶Carbapenemsdecrease the concentr ...

Antiepileptics(continued) ▶Antiepileptics(fosphenytoin, phenytoin)slightly decrease the exposure toefavirenzandefavirenzaffects ...

toiron chelators(deferasirox). Monitor serum ferritin and adjust dose.oTheoretical ▶Isoniazidincreases the concentration ofantie ...

Antiepileptics(continued) ▶Carbamazepinepotentially decreases the exposure to olanzapine. Monitor and adjust dose.oStudy ▶Phenyt ...

torisperidone. Adjust dose.oStudy→Also seeTABLE 11 p. 849 ▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital, phenytoin, ...

Antiepileptics(continued) ▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone)are predicted to decr ...

▶Antacidsdecrease the absorption ofitraconazole(capsule). Antacidsshould be taken 1 hour before or 2 hours after itraconazole.oS ...

Antifungals, azoles(continued) ▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole) are predicted to increase the expo ...

▶Itraconazolepotentially increases the anticoagulant effect of coumarins.rAnecdotal ▶Ketoconazolepotentially increases the antic ...

Antifungals, azoles(continued) ▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are predicted to moderately to mark ...

▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole) are predicted to increase the exposure tonaloxegol. Adjust naloxe ...