BNF for Children (BNFC) 2018-2019

Antifungals, azoles(continued) ▶Proton pump inhibitorsdecrease the absorption of posaconazole(oral suspension). Avoid.oStudy ▶Vo ...

▶Antifungals, azoles(fluconazole, miconazole)are predicted to increase the exposure tosulfonylureas. Use with caution and adjust ...

Antihistamines, non-sedating(continued) ▶Calcium channel blockers(diltiazem, verapamil)are predicted to increase the exposure to ...

▶Calcium salts(calcium carbonate)are predicted to decrease the absorption ofproguanil. Separate administration by at least 2 hou ...

Apremilast(continued) ▶Enzalutamidemoderately decreases the exposure to apremilast. Avoid.rStudy ▶Mitotanemoderately decreases t ...

▶Aprepitantis predicted to decrease the efficacy of norethisterone. For FSRH guidance, seeContraceptives, interactionsp. 497.rAn ...

Asparaginase(continued) ▶Asparaginaseis predicted to increase the risk of hepatotoxicity when given withimatinib.rTheoretical→Al ...

▶Febuxostatis predicted to increase the exposure to azathioprine. Avoid.rTheoretical ▶Live vaccinesare predicted to increase the ...

Beta blockers, non-selective(continued) ▶Antiepileptics(phenobarbital, primidone)are predicted to decrease the exposure topropra ...

▶Beta blockers, selectiveincrease the risk of hypertension and bradycardia when given withsympathomimetics, inotropic (dobutamin ...

Blinatumomab→see monoclonal antibodies Bortezomib→seeTABLE 8p. 848 (hypotension),TABLE 15p. 850 (myelosuppression),TABLE 12p. 85 ...

▶Bosentanis predicted to decrease the exposure toribociclib. oStudy ▶Rifampicinaffects the exposure tobosentan. Avoid.r Study ▶B ...

Buclizine→see antihistamines, sedating Budesonide→see corticosteroids Bumetanide→see loop diuretics Bupivacaine→see anaesthetics ...

▶Cobicistatslightly increases the exposure tocabozantinib. oStudy ▶Cabozantinibis predicted to increase the risk of bleeding eve ...

Calcium channel blockers(continued) ▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are predicted to increase the ...

▶Calcium channel blockers(diltiazem, verapamil)are predicted to increase the risk of ergotism when given withergometrine. rTheor ...

Calcium channel blockers(continued) ▶Calcium channel blockers(diltiazem, verapamil)are predicted to increase the exposure toopio ...

▶Intravenouscalcium saltsincrease the concentration of digoxin. Avoid.oAnecdotal ▶Oralcalcium saltsdecrease the absorption ofdol ...

Cephalosporins(continued) ▶Ceftriaxoneincreases the risk of cardio-respiratory arrest when given withcalcium salts(calcium chlor ...

▶Chloramphenicolpotentially increases the anticoagulant effect ofcoumarins.oAnecdotal ▶Chloramphenicolis predicted to increase t ...