BNF for Children (BNFC) 2018-2019

Ciclosporin(continued) ▶Lanreotideis predicted to decrease the absorption of oral ciclosporin. Adjust dose.rTheoretical ▶Live va ...

▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone)are predicted to decrease the exposure tocinaca ...

Clopidogrel(continued) ▶Clopidogrelincreases the exposure torepaglinide. Avoid. rStudy ▶Clopidogrelis predicted to increase the ...

▶Cobicistatis predicted to increase the exposure to corticosteroids(betamethasone, budesonide, ciclesonide, deflazacort, dexamet ...

Cobicistat(continued) ▶Cobicistatis predicted to increase the exposure toretinoids (alitretinoin). Adjustalitretinoindose.oTheor ...

▶Ciclosporinincreases the exposure tocolchicine. Avoid or adjustcolchicinedose.rStudy ▶Cobicistatis predicted to increase the ex ...

Combined hormonal contraceptives(continued) ▶Paritaprevir(with ritonavir and ombitasvir) increases the risk of raised liver func ...

▶Imatinibis predicted to increase the exposure to methylprednisolone. Monitor and adjust dose.oStudy ▶Corticosteroidsare predict ...

Coumarins(continued) ▶Disulfiramincreases the anticoagulant effect ofcoumarins. Monitor and adjust dose.rStudy ▶Efavirenzis pred ...

▶Crizotinibis predicted to increase the exposure to antiarrhythmics(propafenone). Monitor and adjust dose. oStudy ▶Antiepileptic ...

Crizotinib(continued) ▶Crizotinibis predicted to increase the exposure to phosphodiesterase type-5 inhibitors(vardenafil). Adjus ...

▶Idelalisibis predicted to increase the exposure todabrafenib. Use with caution or avoid.oStudy→Also seeTABLE 15 p. 850 ▶Macroli ...

Darifenacin(continued) ▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole) are predicted to slightly increase the exp ...

Deflazacort→see corticosteroids Delamanid→seeTABLE 9p. 849 (QT-interval prolongation) ▶Antiepileptics(carbamazepine, fosphenytoi ...

Didanosine(continued) ▶Didanosineincreases the risk of toxicity when given with stavudine. Avoid.rStudy→Also seeTABLE 12p. 850 ▶ ...

▶Disulfiramis predicted to increase the anticoagulant effect of phenindione.rTheoretical Dobutamine→see sympathomimetics, inotro ...

Dopamine receptor agonists(continued) (pramipexole). Adjust dose.oTheoretical→Also see TABLE 8p. 848 ▶Droperidolis predicted to ...

▶Rifampicinis predicted to decrease the exposure toduloxetine. oTheoretical ▶SSRIs(fluvoxamine)markedly increase the exposure to ...

Efavirenz(continued) ▶Efavirenzis predicted to decrease the exposure tocrizotinib. Avoid.rTheoretical→Also seeTABLE 9p. 849 ▶Efa ...

▶HIV-protease inhibitorsslightly to moderately increase the exposure toelbasvir. Avoid.oStudy ▶Idelalisibslightly to moderately ...