BNF for Children (BNFC) 2018-2019

Idelalisib(continued) ▶Idelalisibis predicted to increase the exposure totoremifene. oTheoretical ▶Idelalisibis predicted to inc ...

▶Macrolides(clarithromycin)are predicted to increase the exposure toimatinib.oStudy ▶Macrolides(erythromycin)are predicted to in ...

Irinotecan(continued) ▶Live vaccinesare predicted to increase the risk of generalised infection (possibly life-threatening) when ...

▶Isoniazidis predicted to increase the risk of peripheral neuropathy when given withdidanosine.rTheoretical→ Also seeTABLE 1p. 8 ...

Ixazomib ▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital, phenytoin, primidone)are predicted to decrease the exposure ...

▶St John’s Wortis predicted to decrease the exposure to lapatinib. Avoid.rStudy ▶Lapatinibslightly increases the exposure totaxa ...

Levodopa(continued) ▶Isoniaziddecreases the effects oflevodopa.oStudy ▶Levodopais predicted to increase the risk of elevated blo ...

Avoid and for 1 week after stoppingsafinamide.r Theoretical→Also seeTABLE 13p. 850 ▶Reboxetineis predicted to increase the risk ...

Live vaccines(continued) ▶Live vaccinesare predicted to increase the risk of generalised infection (possibly life-threatening) w ...

▶Antiarrhythmics(amiodarone)are predicted to increase the exposure tolomitapide. Separate administration by 12 hours. oTheoretic ...

Loperamide(continued) ▶Mirabegronis predicted to increase the exposure to loperamide.nTheoretical ▶Opicaponeis predicted to incr ...

▶Rifampicinis predicted to decrease the exposure to macitentan. Avoid.rStudy ▶St John’s Wortis predicted to decrease the exposur ...

Macrolides(continued) ▶Clarithromycinis predicted to moderately increase the exposure tocilostazol. Adjustcilostazoldose.oStudy ...

▶Clarithromycinincreases the exposure toHIV-protease inhibitors (saquinavir)andHIV-protease inhibitors(saquinavir)increase the e ...

Macrolides(continued) ▶Erythromycinis predicted to increase the exposure to phosphodiesterase type-5 inhibitors(vardenafil). Adj ...

▶Clarithromycinis predicted to increase the exposure to venetoclax. Avoid potent inhibitors of CYP3A4 or adjust venetoclaxdose.r ...

Mesalazine ROUTE-SPECIFIC INFORMATIONThe manufacturers of some mesalazine gastro-resistant and modified-release medicines (Asaco ...

▶Metronidazoleincreases the risk of toxicity when given with alkylating agents(busulfan).rStudy ▶Antiepileptics(phenobarbital, p ...

Midostaurin(continued) ▶HIV-protease inhibitorsare predicted to very markedly increase the exposure tomidostaurin. Avoid or moni ...

▶Mitotaneis predicted to markedly decrease the exposure to aprepitant. Avoid.oStudy ▶Mitotaneis predicted to moderately decrease ...