▶Antiarrhythmics(amiodarone)are predicted to increase the
exposure tolomitapide. Separate administration by 12 hours.
oTheoretical
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure tolomitapide. Avoid.oTheoretical
▶Antiepileptics(carbamazepine, fosphenytoin, phenobarbital,
phenytoin, primidone)are predicted to decrease the exposure
tolomitapide. Monitor and adjust dose.oTheoretical→
Also seeTABLE 1p. 847
▶Antifungals, azoles(clotrimazole)are predicted to increase the
exposure tolomitapide. Separate administration by 12 hours.
oTheoretical
▶Antifungals, azoles(fluconazole, isavuconazole, posaconazole)
are predicted to increase the exposure tolomitapide. Avoid.
oTheoretical→Also seeTABLE 1p. 847
▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are
predicted to markedly increase the exposure tolomitapide.
Avoid.rStudy→Also seeTABLE 1p. 847
▶Aprepitantis predicted to increase the exposure tolomitapide.
Avoid.oTheoretical
▶Bicalutamideis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Calcium channel blockers(amlodipine, lacidipine)are predicted
to increase the exposure tolomitapide. Separate
administration by 12 hours.oTheoretical
▶Calcium channel blockers(diltiazem, verapamil)are predicted to
increase the exposure tolomitapide. Avoid.oTheoretical
▶Ciclosporinis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Cilostazolis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Cobicistatis predicted to markedly increase the exposure to
lomitapide. Avoid.rStudy
▶Oralcombined hormonal contraceptivesslightly increase the
exposure tolomitapide. Separate administration by 12 hours.
oTheoretical
▶Lomitapideincreases the exposure tocoumarins(warfarin).
Monitor INR and adjust dose.rStudy
▶Crizotinibis predicted to increase the exposure tolomitapide.
Avoid.oTheoretical
▶Enzalutamideis predicted to decrease the exposure to
lomitapide. Monitor and adjust dose.oTheoretical
▶Everolimusis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Fosaprepitantis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Grapefruit juiceis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶H 2 receptor antagonists(cimetidine, ranitidine)are predicted to
increase the exposure tolomitapide. Separate administration
by 12 hours.oTheoretical
▶HIV-protease inhibitorsare predicted to markedly increase the
exposure tolomitapide. Avoid.rStudy
▶Idelalisibis predicted to markedly increase the exposure to
lomitapide. Avoid.rStudy
▶Imatinibis predicted to increase the exposure tolomitapide.
Avoid.oTheoretical
▶Isoniazidis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.qTheoretical→
Also seeTABLE 1p. 847
▶Ivacaftoris predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Lapatinibis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Linagliptinis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Macrolides(azithromycin)are predicted to increase the
exposure tolomitapide. Separate administration by 12 hours.
oTheoretical
▶Macrolides(clarithromycin)are predicted to markedly increase
the exposure tolomitapide. Avoid.rStudy
▶Macrolides(erythromycin)are predicted to increase the
exposure tolomitapide. Avoid.oTheoretical
▶Mitotaneis predicted to decrease the exposure tolomitapide.
Monitor and adjust dose.oTheoretical
▶Netupitantis predicted to increase the exposure tolomitapide.
Avoid.oTheoretical
▶Nilotinibis predicted to increase the exposure tolomitapide.
Avoid.oTheoretical
▶Pazopanibis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Peppermint oilis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Propiverineis predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Ranolazineis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Rifampicinis predicted to decrease the exposure tolomitapide.
Monitor and adjust dose.oTheoretical
▶SSRIs(fluoxetine)are predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.q
Theoretical
▶SSRIs(fluvoxamine)are predicted to increase the exposure to
lomitapide. Separate administration by 12 hours.o
Theoretical
▶Lomitapideincreases the exposure tostatins(atorvastatin).
Adjustlomitapidedose or separate administration by
12 hours.nStudy→Also seeTABLE 1p. 847
▶Lomitapideincreases the exposure tostatins(simvastatin).
Monitor and adjustsimvastatindose,p. 134.oStudy→
Also seeTABLE 1p. 847
▶Tacrolimusis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Ticagreloris predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
▶Tolvaptanis predicted to increase the exposure tolomitapide.
Separate administration by 12 hours.oTheoretical
Lomustine→see alkylating agents
Loop diuretics→seeTABLE 18p. 851 (hyponatraemia),TABLE 8p. 848
(hypotension),TABLE 19p. 851 (ototoxicity),TABLE 17p. 851 (reduced
serum potassium)
bumetanide.furosemide.torasemide..
▶Aliskirenslightly decreases the exposure tofurosemide.
oStudy→Also seeTABLE 8p. 848
▶Loop diureticsincrease the risk of nephrotoxicity when given
withaminoglycosides. Avoid.oStudy→Also seeTABLE 19
p. 851
▶Antiepileptics(fosphenytoin, phenytoin)decrease the effects of
furosemide.oStudy
▶Intravenousfurosemidepotentially increases the risk of
sweating, variable blood pressure, and tachycardia when
given afterchloral hydrate.oAnecdotal
▶Dasabuvir(with ombitasvir, paritaprevir and ritonavir)
increases the concentration offurosemide. Adjust dose.
oStudy
▶Loop diureticsincrease the concentration oflithium. Monitor
and adjust dose.rStudy
▶Paritaprevir(with ritonavir and ombitasvir) is predicted to
increase the exposure tofurosemide. Adjust dose.o
Theoretical
▶Reboxetineis predicted to increase the risk of hypokalaemia
when given withloop diuretics.oTheoretical
Loperamide
▶Antiarrhythmics(dronedarone)are predicted to increase the
exposure toloperamide.rTheoretical
▶Ceritinibis predicted to increase the exposure toloperamide.
oTheoretical
▶Loperamidegreatly increases the absorption of oral
desmopressin(and possibly sublingual).oStudy
▶Eliglustatis predicted to increase the exposure toloperamide.
Adjust dose.oStudy
▶Lapatinibis predicted to increase the exposure toloperamide.
oTheoreticalBNFC 2018 – 2019 Lomitapide—Loperamide 945
Interactions|Appendix 1A1