BNF for Children (BNFC) 2018-2019

Mitotane(continued) ▶Mitotaneis predicted to decrease the exposure topaliperidone. Monitor and adjust dose.rStudy ▶Mitotaneis pr ...

▶Methylphenidateis predicted to increase the risk of a hypertensive crisis when given withmoclobemide.r Theoretical ▶Mianserinis ...

Monoamine-oxidase A and B inhibitors, irreversible(continued) ▶Monoamine-oxidase A and B inhibitors, irreversibleare predicted t ...

▶Quinolones(ciprofloxacin)slightly increase the exposure to rasagiline.oStudy ▶Reboxetineis predicted to increase the risk of a ...

Moxonidine(continued) ▶Tricyclic antidepressantsare predicted to decrease the effects ofmoxonidine. Avoid.oTheoretical→Also seeT ...

▶Netupitantis predicted to increase the exposure to antihistamines, non-sedating(rupatadine). Avoid.oStudy ▶Netupitantis predict ...

Netupitant(continued) ▶St John’s Wortis predicted to decrease the exposure to netupitant.oTheoretical ▶Netupitantis predicted to ...

▶Nevirapineis predicted to decrease the exposure to glecaprevir. Avoid.rStudy ▶Nevirapineis predicted to markedly decrease the e ...

Nilotinib(continued) ▶Nilotinibis predicted to increase the exposure tocabozantinib. oTheoretical→Also seeTABLE 15p. 850→Also se ...

▶Nilotinibis predicted to increase the exposure toSSRIs (dapoxetine). Adjustdapoxetinedose with moderate inhibitors of CYP3A4.oT ...

Norethisterone(continued) ▶Rifabutinis predicted to decrease the efficacy of norethisterone. For FSRH guidance, seeContraceptive ...

▶Antifungals, azoles(itraconazole, ketoconazole, voriconazole)are predicted to increase the exposure toolaparib. Avoid potent in ...

Opioids(continued) buprenorphine, fentanyl, oxycodone). Monitor and adjust dose. oStudy ▶Antifungals, azoles(itraconazole, ketoc ...

▶Palbociclibis predicted to increase the exposure toopioids (alfentanil, fentanyl). Adjust dose.oTheoretical ▶Pitolisantis predi ...

Paliperidone(continued) ▶Antiepileptics(valproate)slightly increase the exposure to paliperidone. Adjust dose.oStudy ▶Paliperido ...

▶Efavirenzis predicted to decrease the exposure toparitaprevir (with ritonavir and ombitasvir). Avoid.rStudy ▶Enzalutamideis pre ...

Penicillamine(continued) ▶Iron (oral)is predicted to decrease the absorption of penicillamine. Separate administration by at lea ...

▶Amfetaminesare predicted to decrease the effects of chlorpromazine.oStudy ▶Phenothiazinesare predicted to decrease the effects ...

Phosphodiesterase type-5 inhibitors(continued) ▶Enzalutamideis predicted to decrease the exposure to phosphodiesterase type-5 in ...

▶Pibrentasvir(with glecaprevir) increases the exposure to statins(rosuvastatin). Use with caution and adjustrosuvastatin dose,p. ...