Science - USA (2021-07-16)

PUT HUMAN HEALTH AT THE HEART OF YOUR RESEARCH ScienceTranslationalMedicine.org Submityourresearch: cts.ScienceMag.org Twitter:@ ...

RESEARCH ARTICLE SUMMARY ◥ DEVELOPMENTAL BIOLOGY Generation of ovarian follicles from mouse pluripotent stem cells Takashi Yoshi ...

RESEARCH ARTICLE ◥ DEVELOPMENTAL BIOLOGY Generation of ovarian follicles from mouse pluripotent stem cells Takashi Yoshino^1 , T ...

addition, Sonic hedgehog (SHH) is involved in specification of the ventromedial coelomic epithelium in chick embryos ( 13 ). The ...

expression (fig. S4C). Q-PCR reinforced the slight up-regulation ofGata4,Lhx9, andWt1, functional marker genes for gonadal somat ...

PGCLCs alone in culture were degraded by D14 (fig. S7A). PGCLCs in the reaggregates expressed SC and BV at D2, down-regulated th ...

it became comparable in rOvarioids with 100,000 FOSLCs (Fig. 3B). The productivity was not improved in rOvarioids with 120,000 F ...

proliferate to form germ cell cysts with ex- pression of DDX4, a later germ cell marker (Fig. 3D and fig. S8, A and B). At D7, P ...

produce FOSLCs and PGCLCs, which are equiv- alent to nascent gonadal somatic cells and premigratory PGCs ( 6 ), respectively, it ...

they have full potency to support oogenesis. For these reasons, this system will be a use- ful tool for solving key issues in re ...

RESEARCH ARTICLE SUMMARY ◥ CORONAVIRUS Estimating epidemiologic dynamics from cross-sectional viral load distributions James A. ...

RESEARCH ARTICLE ◥ CORONAVIRUS Estimating epidemiologic dynamics from cross-sectional viral load distributions James A. Hay1,2,3 ...

of viral RNA, although there is substantial sampling and viral load variability at all time points (Fig. 1D). The overall distri ...

growth rater> 0) will have a predominance of new infections and thus of high viral loads, and shrinking epidemics (Rt<1and ...

Hayet al.,Science 373 , eabh0635 (2021) 16 July 2021 4 of 12 0 2 4 6 B 8 0 2 4 6 8 Count 0 2 4 6 8 30 2 0 01 Ct value 0.00 0.25 ...

Although no real long-term care facility data were available to assess the method’s accuracy during the early phase of the epide ...

With the objective of reconstructing the en- tire incidence curve using routinely collected RT-qPCR data, we used anonymized Ct ...

We assessed the robustness of the estimated GP trajectory to smaller sample sizes by refitting the model after subsampling diffe ...

pandemic and the relationship between inci- dence rate, time since infection, and virologic test results to estimate a community ...

Ct distribution parameters from different set- tings are comparable. Because of this, semi- quantitative measures from RT-qPCR s ...